Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

Zorica Nesic; Zoran Todorovic; Radan Stojanovic; Gordana Basta-Jovanovic; Sanja Radojevic-Skodric; Ruzica Velickovic; Prabal K. Chatterjee; Christoph Thiemermann; Milica Prostran

doi:10.1254/jphs.SCE06002X

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Single-Dose Intravenous Simvastatin Treatment Attenuates Renal Injury in an Experimental Model of Ischemia-Reperfusion in the Rat

Zorica Nesic, Zoran Todorovic, Radan Stojanovic, Gordana Basta-Jovanovic, Sanja Radojevic-Skodric, Ruzica Velickovic, Prabal K. Chatterjee, Christoph Thiemermann, Milica Prostran

Author information

Zorica Nesic
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Zoran Todorovic
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Radan Stojanovic
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro
Gordana Basta-Jovanovic
Department of Pathology, School of Medicine, University of Belgrade, Serbia and Montenegro
Sanja Radojevic-Skodric
Department of Pathology, School of Medicine, University of Belgrade, Serbia and Montenegro
Ruzica Velickovic
Institute of Mental Health, Laboratory of Biochemistry, Serbia and Montenegro
Prabal K. Chatterjee
School of Pharmacy & Biomolecular Sciences, University of Brighton, United Kingdom
Christoph Thiemermann
The William Harvey Research Institute, St. Bartholomew’s and Royal London School of Medicine and Dentistry, United Kingdom
Milica Prostran
Department of Pharmacology, Clinical Pharmacology and Toxicology, School of Medicine, University of Belgrade, Serbia and Montenegro

Keywords: simvastatin, ischemia-reperfusion renal injury, acute renal failure

JOURNAL FREE ACCESS

2006 Volume 102 Issue 4 Pages 413-417

DOI https://doi.org/10.1254/jphs.SCE06002X

View "Advance Publication" version (November 28, 2006).

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Abstract

The effect of acute pretreatment with a single dose of simvastatin (1 mg/kg, i.v.; 30 min before ischemia) on renal dysfunction caused by ischemia-reperfusion (I/R) injury in the rat was investigated. I/R injury was induced by clamping both renal vascular pedicles for 45 min, followed by 4 h of reperfusion with saline (2 ml/kg per hour). Simvastatin significantly improved both parameters of glomerular and tubular dysfunction (e.g., creatinine levels and fractional excretion of Na⁺, respectively) and especially improved the histological score, compared to control I/R-injured rats treated with saline or 10% DMSO only.

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