The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Yukio Ago; Ryota Araki; Koji Yano; Toshiyuki Kawasaki; Shigeyuki Chaki; Atsuro Nakazato; Hirotaka Onoe; Hitoshi Hashimoto; Akemichi Baba; Kazuhiro Takuma; Toshio Matsuda

doi:10.1254/jphs.11200SC

Short Communications

The Selective Metabotropic Glutamate 2/3 Receptor Agonist MGS0028 Reverses Isolation Rearing–Induced Abnormal Behaviors in Mice

Yukio Ago, Ryota Araki, Koji Yano, Toshiyuki Kawasaki, Shigeyuki Chaki, Atsuro Nakazato, Hirotaka Onoe, Hitoshi Hashimoto, Akemichi Baba, Kazuhiro Takuma, Toshio Matsuda

Author information

Yukio Ago
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Ryota Araki
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Koji Yano
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Toshiyuki Kawasaki
Functional Probe Research Laboratory, RIKEN, Center for Molecular Imaging Science, Kobe MI R&D Center, Japan
Shigeyuki Chaki
Molecular Function and Pharmacology Laboratories, Taisho Pharmaceutical Co., Ltd., Japan
Atsuro Nakazato
Strategic Planning of Drug Discovery, R&D Headquarters of Pharmaceutical Operation, Taisho Pharmaceutical Co., Ltd., Japan
Hirotaka Onoe
Functional Probe Research Laboratory, RIKEN, Center for Molecular Imaging Science, Kobe MI R&D Center, Japan
Hitoshi Hashimoto
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka University, Japan
Department of Molecular Pharmaceutical Science, Graduate School of Medicine, Osaka University, Japan
Akemichi Baba
Laboratory of Molecular Neuropharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Hyogo University of Health Sciences, Japan
Kazuhiro Takuma
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
Toshio Matsuda
Laboratory of Medicinal Pharmacology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
United Graduate School of Child Development, Osaka University, Kanazawa University and Hamamatsu University School of Medicine, Osaka University, Japan

Keywords: metabotropic glutamate 2/3 receptor, isolation rearing, behavior

JOURNAL FREE ACCESS

2012 Volume 118 Issue 2 Pages 295-298

DOI https://doi.org/10.1254/jphs.11200SC

View "Advance Publication" version (January 27, 2012).

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Abstract

Isolation-induced abnormal behaviors are useful animal models for assessing potential anti-psychotic drugs. This study examined the effect of MGS0028, a selective metabotropic glutamate 2/3 receptor agonist, on abnormal behaviors such as hyperactivity, aggression, and deficits of prepulse inhibition in isolation-reared mice. MGS0028 attenuated hyperactivity and aggressive behaviors in isolation-reared mice. The agonist also reversed isolation rearing–induced deficits of prepulse inhibition. On the other hand, MGS0028 did not affect locomotor activity and prepulse inhibition in group-reared mice. These results suggest that the metabotropic glutamate 2/3 receptor agonist, MGS0028, is a potential compound for the treatment of psychiatric disorders.

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