1965 Volume 29 Issue 10 Pages 923-930
"Circular deviation ", the particular fluctuation of urea clearance following abrupt change of urine flow was observed in normal adults. This phenomenon was ascertained also in patients with diabetes insipidus by the administration of pitressin. The circular deviation in patients with renal, diseases showed an atypical pattern. These resuls were discussed from the viewpoint of countercurrent hypothesis.