Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
TAVR
Effect of Sex on Mortality and Left Ventricular Remodeling After Transcatheter Aortic Valve Implantation
Koki Shishido, Futoshi Yamanaka, Tomoki Ochiai, Noriaki Moriyama, Hiroaki Yokoyama, Shohei Yokota, Kenichiro Noguchi, Fumiaki Yashima, Norio Tada, Toru Naganuma, Motoharu Araki, Shinichi Shirai, Hiroshi Ueno, Kazuki Mizutani, Minoru Tabata, Kensuke Takagi, Yusuke Watanabe, Masanori Yamamoto, Shigeru Saito, Kentaro Hayashida
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Keywords: Left ventricular mass index (LVMI), Sex difference, Transcatheter aortic valve implantation (TAVI)
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2021 Volume 85 Issue 7 Pages 979-988

Editorial (85-7 pp.989-990)
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Abstract

Background:The effect of sex on mortality is controversial; furthermore, sex differences in left ventricular (LV) remodeling after transcatheter aortic valve implantation (TAVI) remain unknown.

Methods and Results:This study included 2,588 patients (1,793 [69.3%] female) enrolled in the Optimized CathEter vAlvular iNtervention (OCEAN)-TAVI Japanese multicenter registry between October 2013 and May 2017. We retrospectively analyzed the effect of sex on mortality, and evaluated changes in the LV mass index (LVMI) after TAVI. Female sex was significantly associated with lower all-cause and cardiovascular mortality (log-rank P<0.001 for both). Multivariate analysis showed that female sex was independently associated with lower cumulative long-term mortality (hazard ratio 0.615; 95% confidence interval 0.512–0.738; P<0.001). Regression in the LVMI was observed in both sexes, and there was no significant difference in the percentage LVMI regression from baseline to 1 year after TAVI between women and men. Women had a survival advantage compared with men among patients with LVMI regression at 1 year, but not among patients with no LVMI regression.

Conclusions:We found that female sex is associated with better survival outcomes after TAVI in a large Japanese registry. Although LVMI regression was observed in women and men after TAVI, post-procedural LV mass regression may be related to the sex differences in mortality.

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© 2021, THE JAPANESE CIRCULATION SOCIETY

This article is licensed under a Creative Commons [Attribution-NonCommercial-NoDerivatives 4.0 International] license.
https://creativecommons.org/licenses/by-nc-nd/4.0/
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