Circulation Journal
Online ISSN : 1347-4820
Print ISSN : 1346-9843
ISSN-L : 1346-9843
Cardiovascular Intervention
Long-Term Comparison of Platinum Chromium Everolimus-Eluting Stent vs. Cobalt Chromium Zotarolimus-Eluting Stent　― 3-Year Outcomes From the HOST–ASSURE Randomized Clinical Trial ―
Chee Hae Kim, Kyung Woo Park, Jeehoon Kang, Byoung-Eun Park, Kwang Soo Cha, Jay Young Rhew, Hui-Kyung Jeon, Eun-Seok Shin, Ju Hyeon Oh, Myung-Ho Jeong, Sanghyun Kim, Kyung-Kuk Hwang, Jung-Han Yoon, Sung Yun Lee, Tae-Ho Park, Keon Woong Moon, Hyuck-Moon Kwon, Seung-Ho Hur, Jae-Kean Ryu, Bong-Ryul Lee, Yong Whi Park, In-Ho Chae, Hyo-Soo Kim, on behalf of the HOST–ASSURE Investigators
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Keywords: Clinical outcome, Cobalt chromium-based zotarolimus-eluting stent, Drug-eluting stent, Percutaneous coronary intervention, Platinum chromium-based everolimus-eluting stent
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2019 Volume 83 Issue 7 Pages 1489-1497

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Abstract

Background:There are limited data on the long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) vs. cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES).

Methods and Results:A total of 3,755 patients undergoing percutaneous coronary intervention (PCI) were randomized 2:1 to PtCr-EES or CoCr-ZES, and 96.0% of patients completed the 3-year clinical follow-up. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR). At 3 years, TLF occurred in 5.3% and in 5.4% of the PtCr-EES and CoCr-ZES groups, respectively (hazard ratio 0.978; 95% confidence interval 0.730–1.310, P=0.919). There were no significant differences in the individual components of TLF. Routine angiographic follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that had follow-up angiography, the clinically-driven TLR rate of CoCr-ZES was significantly higher than PtCr-EES group during the angiography follow-up period (P=0.009). Overall definite and probable stent thrombosis rates were very low in both groups (0.5% vs. 0.6%, P=0.677).

Conclusions:PtCr-EES and CoCr-ZES had similar and excellent long-term outcomes in both efficacy and safety after PCI in an all-comer population.

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© 2019 THE JAPANESE CIRCULATION SOCIETY
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