Nutrition Status Predicts Severity of Vascular Calcification in Non-Dialyzed Chronic Kidney Disease

Kazuhiro Harada; Susumu Suzuki; Hideki Ishii; Kenshi Hirayama; Toshijiro Aoki; Yohei Shibata; Yosuke Negishi; Takuya Sumi; Kazuhiro Kawashima; Ayako Kunimura; Yosuke Tatami; Toshiki Kawamiya; Dai Yamamoto; Ryota Morimoto; Yoshinari Yasuda; Toyoaki Murohara

doi:10.1253/circj.CJ-16-0911

Aortic Disease

Nutrition Status Predicts Severity of Vascular Calcification in Non-Dialyzed Chronic Kidney Disease

Kazuhiro Harada, Susumu Suzuki, Hideki Ishii, Kenshi Hirayama, Toshijiro Aoki, Yohei Shibata, Yosuke Negishi, Takuya Sumi, Kazuhiro Kawashima, Ayako Kunimura, Yosuke Tatami, Toshiki Kawamiya, Dai Yamamoto, Ryota Morimoto, Yoshinari Yasuda, Toyoaki Murohara

Author information

Kazuhiro Harada
Department of Cardiology, Nagoya University Graduate School of Medicine
Susumu Suzuki
Department of Cardiology, Nagoya University Graduate School of Medicine
Hideki Ishii
Department of Cardiology, Nagoya University Graduate School of Medicine
Kenshi Hirayama
Department of Cardiology, Nagoya University Graduate School of Medicine
Toshijiro Aoki
Department of Cardiology, Nagoya University Graduate School of Medicine
Yohei Shibata
Department of Cardiology, Nagoya University Graduate School of Medicine
Yosuke Negishi
Department of Cardiology, Nagoya University Graduate School of Medicine
Takuya Sumi
Department of Cardiology, Nagoya University Graduate School of Medicine
Kazuhiro Kawashima
Department of Cardiology, Nagoya University Graduate School of Medicine
Ayako Kunimura
Department of Cardiology, Nagoya University Graduate School of Medicine
Yosuke Tatami
Department of Cardiology, Nagoya University Graduate School of Medicine
Toshiki Kawamiya
Department of Cardiology, Nagoya University Graduate School of Medicine
Dai Yamamoto
Department of Cardiology, Nagoya University Graduate School of Medicine
Ryota Morimoto
Department of Cardiology, Nagoya University Graduate School of Medicine
Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine
Yoshinari Yasuda
Department of CKD Initiatives Internal Medicine, Nagoya University Graduate School of Medicine
Toyoaki Murohara
Department of Cardiology, Nagoya University Graduate School of Medicine

Keywords: Aortic calcification index, Geriatric nutritional risk index, Nutrition status

JOURNAL FREE ACCESS FULL-TEXT HTML

2017 Volume 81 Issue 3 Pages 316-321

DOI https://doi.org/10.1253/circj.CJ-16-0911

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Abstract

Background:Vascular calcification is a major complication in chronic kidney disease (CKD) that increases the risk of adverse clinical outcomes. Geriatric nutritional risk index (GNRI) is a simple nutritional assessment tool that predicts poor prognosis in elderly subjects. The purpose of the present study was to evaluate the correlation between GNRI and severity of vascular calcification in non-dialyzed CKD patients.

Methods and Results:We enrolled 323 asymptomatic CKD patients. To evaluate abdominal aortic calcification (AAC), we used aortic calcification index (ACI) determined on non-contrast computed tomography. The patients were divided into three groups according to GNRI tertile. Median ACI significantly decreased with increasing GNRI tertile (15.5%, 13.6%, and 7.9%, respectively; P=0.001). On multivariate regression analysis GNRI was significantly correlated with ACI (β=−0.15, P=0.009). We also investigated the combination of GNRI and C-reactive-protein (CRP) for predicting the severity of AAC. Low GNRI and high CRP were significantly associated with severe AAC, compared with high GNRI and low CRP (OR, 4.07; P=0.004).

Conclusions:GNRI was significantly associated with AAC in non-dialyzed CKD patients.

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