Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy A Niigata Multicenter Study of DCM

Satoru Komura; Masaomi Chinushi; Michiko Kudo; Takashi Saikawa; Yasutaka Tanabe; Hiroshi Furushima; Takashi Washizuka; Makoto Kodama; Hirotaka Oda; Seiichi Miyajima; Fumiaki Masani; Yutaka Igarashi; Minoru Murata; Yoshifusa Aizawa

doi:10.1253/circj.68.1104

Clinical Investigation

Potential Candidates for Cardiac Resynchronization Therapy in Japanese Patients With Idiopathic Dilated Cardiomyopathy

A Niigata Multicenter Study of DCM

Satoru Komura, Masaomi Chinushi, Michiko Kudo, Takashi Saikawa, Yasutaka Tanabe, Hiroshi Furushima, Takashi Washizuka, Makoto Kodama, Hirotaka Oda, Seiichi Miyajima, Fumiaki Masani, Yutaka Igarashi, Minoru Murata, Yoshifusa Aizawa

Author information

Satoru Komura
From the First Department of Internal Medicine, Division of Cardiology
Masaomi Chinushi
From the First Department of Internal Medicine, Division of Cardiology
Michiko Kudo
Niigata Prefectural Central Hospital
Takashi Saikawa
From the First Department of Internal Medicine, Division of Cardiology
Yasutaka Tanabe
From the First Department of Internal Medicine, Division of Cardiology
Hiroshi Furushima
From the First Department of Internal Medicine, Division of Cardiology
Takashi Washizuka
From the First Department of Internal Medicine, Division of Cardiology
Makoto Kodama
From the First Department of Internal Medicine, Division of Cardiology
Hirotaka Oda
Niigata City General Hospital
Seiichi Miyajima
Tsubame Rousai Hospital
Fumiaki Masani
Niigata Prefectural Central Hospital
Yutaka Igarashi
Tsuruoka City Shonai Hospital
Minoru Murata
Mito Saiseikai Hospital
Yoshifusa Aizawa
From the First Department of Internal Medicine, Division of Cardiology
Author's Organization：
School of Health Science, Niigata University School of Medicine

Keywords: Cardiac resynchronization therapy, Idiopathic dilated cardiomyopathy, QRS duration

JOURNAL FREE ACCESS

2004 Volume 68 Issue 12 Pages 1104-1109

DOI https://doi.org/10.1253/circj.68.1104

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Abstract

Background The purpose of this study was to assess the candidates suitable for cardiac resynchronization therapy (CRT) and to examine the significance of the QRS duration in Japanese patients with idiopathic dilated cardiomyopathy (DCM). Methods and Results The study population consisted of 357 patients. The selection criteria for candidates suitable for CRT were QRS duration =130 ms, left ventricular ejection fraction (LVEF) =35% and New York Heart Association (NYHA) functional class III or IV by ACC/AHA/NASPE 2002 guidelines. We divided the study population into 2 groups: group A with a QRS duration <130 ms, and group B with a QRS duration =130 ms. In 25 of the 375 patients (7.0%), all the criteria were fulfilled. Group B had a significantly larger left ventricular diameter end-diastole and end-systole than group A (P<0.0001). Group B had a lower LVEF (P<0.0001). There was a fair inverse correlation (r=-0.58, P<0.0001) between the length of the QRS duration and LVEF. Conclusion Approximately 7% of the Japanese patients with DCM are CRT candidates. In the present study, we found that prolonged QRS duration was associated with poor systolic function. (Circ J 2004; 68: 1104 - 1109)

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