Antinociceptive and Anti-inflammatory Properties of Corchorus capsularis Leaves Chloroform Extract in Experimental Animal Models

Zainul Amiruddin ZAKARIA; Mohd. Roslan SULAIMAN; Hanan Kumar GOPALAN; Zuleen Delina Fasya ABDUL GHANI; Raden Nur Suraya RADEN MOHD. NOR; Abdul Manan MAT JAIS; Fatimah Corazon ABDULLAH

doi:10.1248/yakushi.127.359

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Antinociceptive and Anti-inflammatory Properties of Corchorus capsularis Leaves Chloroform Extract in Experimental Animal Models

Zainul Amiruddin ZAKARIA, Mohd. Roslan SULAIMAN, Hanan Kumar GOPALAN, Zuleen Delina Fasya ABDUL GHANI, Raden Nur Suraya RADEN MOHD. NOR, Abdul Manan MAT JAIS, Fatimah Corazon ABDULLAH

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Keywords: Corchorus capsularis, chloroform extract, antinociceptive activity, anti-inflammatory activity

JOURNAL FREE ACCESS

2007 Volume 127 Issue 2 Pages 359-365

DOI https://doi.org/10.1248/yakushi.127.359

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Abstract

The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72 h soaking of the air-dried leaves in chloroform followed by in vacuo evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200 mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.

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