Chemical Synthesis and Evaluation of Exopolysaccharide Fragments Produced by Leuconostoc mesenteroides Strain NTM048

Shinsuke Inuki; Hitomi Tabuchi; Chiaki Matsuzaki; Yasunori Yonejima; Keiko Hisa; Ikuo Kimura; Kenji Yamamoto; Hiroaki Ohno

doi:10.1248/cpb.c21-00919

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Chemical Synthesis and Evaluation of Exopolysaccharide Fragments Produced by Leuconostoc mesenteroides Strain NTM048

Shinsuke Inuki , Hitomi Tabuchi, Chiaki Matsuzaki, Yasunori Yonejima, Keiko Hisa, Ikuo Kimura, Kenji Yamamoto, Hiroaki Ohno

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Keywords: exopolysaccharide, Leuconostoc mesenteroides, glycosylation, fragment synthesis, immunomodulatory activity

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2022 Volume 70 Issue 2 Pages 155-161

DOI https://doi.org/10.1248/cpb.c21-00919

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Abstract

Exopolysaccharides (EPSs) occur widely in natural products made by bacteria, fungi and algae. Some EPSs have intriguing biological properties such as anticancer and immunomodulatory activities. Our group has recently found that EPSs generated from Leuconostoc mesenteroides ssp. mesenteroides strain NTM048 (NTM048 EPS) enhanced a production of mucosal immunoglobulin A (IgA) of mouse. Herein, we described the synthesis and evaluation of the tetrasaccharide fragments of NTM048 EPS to obtain information about the molecular mechanism responsible for the IgA-inducing activity.

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