Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
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Synthesis, Aggregation Behavior, and Photodynamic Properties of a Water-Soluble Fulleropyrrolidine Bearing an N-PEG Pyridinium Unit
Keiji Mizuki , Seigo Matsumoto, Taro Honda, Kouhei Maeda, Satoshi Toyama, Daisuke Iohara, Fumitoshi Hirayama, Shoko Okazaki, Keizo Takeshita, Taizo Hatta
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Keywords: fullerene derivative, polyethylene glycol, photodynamic activity
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2018 Volume 66 Issue 8 Pages 822-825

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Abstract

Herein, we describe the synthesis of a water-soluble photodynamically active fullerene bearing a polyethylene glycol chain and a hydrophilic cationic group, revealing that the solubility of the above derivative in aqueous medium depends on ultrasonication time, with the particle size of aggregates being correlated with concentration.

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© 2018 The Pharmaceutical Society of Japan
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