New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica

Retno Widyowati; Sachiko Sugimoto; Yoshi Yamano; Sukardiman; Hideaki Otsuka; Katsuyoshi Matsunami

doi:10.1248/cpb.c16-00073

Notes

New Isolinariins C, D and E, Flavonoid Glycosides from Linaria japonica

Retno Widyowati, Sachiko Sugimoto, Yoshi Yamano, Sukardiman, Hideaki Otsuka, Katsuyoshi Matsunami

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Keywords: Linaria japonica, cytotoxicity, collagenase, advanced glycation end product, flavonoid glycoside

JOURNAL FREE ACCESS FULL-TEXT HTML

2016 Volume 64 Issue 5 Pages 517-521

DOI https://doi.org/10.1248/cpb.c16-00073

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Abstract

Three new flavonoid glycosides named isolinariins C, D and E (1–3), two known flavonoid glycosides (4, 5) and three known flavonoids (6–8) were isolated from the whole plant of Linaria japonica. The structures of these compounds were determined mainly by spectroscopic analyses. The bioactivities of these isolated compounds were evaluated for their inhibitory activities against human cell line A549, collagenase, and advanced glycation end product (AGE) formation. Among the isolated compounds, isolinariins C, D and E (1, 2 and 3) showed inhibition toward AGE formation (IC₅₀ values of 34.8, 35.0 and 19.5 µM, respectively). And linariin (4), pectolinarin (5) and luteolin (8) were found to be active against collagenase with IC₅₀ values of 79.4, 78.6 and 40.5 µM, respectively, without significant cytotoxicity at these concentrations.

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