Molecular Symmetry and Biological Activities of New Symmetrical Tris(2-aminoethyl)amine Derivatives

Nobuko Mibu; Kazumi Yokomizo; Wataru Uchida; Satoshi Takemura; Jianrong Zhou; Hatsumi Aki; Takeshi Miyata; Kunihiro Sumoto

doi:10.1248/cpb.60.408

Notes

Molecular Symmetry and Biological Activities of New Symmetrical Tris(2-aminoethyl)amine Derivatives

Nobuko Mibu, Kazumi Yokomizo, Wataru Uchida, Satoshi Takemura, Jianrong Zhou, Hatsumi Aki, Takeshi Miyata, Kunihiro Sumoto

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Keywords: tris(2-aminoethyl)amine, tripodal, anti-herpes simplex virus type 1, C₃ symmetry, C_S symmetry, plaque reduction assay

JOURNAL FREE ACCESS

2012 Volume 60 Issue 3 Pages 408-414

DOI https://doi.org/10.1248/cpb.60.408

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Abstract

In terms of molecular symmetry and bioactivity, new C₃- and C_S-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.

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