Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

Phan Van Kiem; Hoang Le Tuan Anh; Nguyen Xuan Nhiem; Chau Van Minh; Nguyen Thi Kim Thuy; Pham Hai Yen; Dan Thuy Hang; Bui Huu Tai; Vivek Bhakta Mathema; Young-Sang Koh; Young Ho Kim

doi:10.1248/cpb.60.246

Notes

Labdane-Type Diterpenoids from the Rhizomes of Hedychium coronarium Inhibit Lipopolysaccharide-Stimulated Production of Pro-inflammatory Cytokines in Bone Marrow-Derived Dendritic Cells

Phan Van Kiem, Hoang Le Tuan Anh, Nguyen Xuan Nhiem, Chau Van Minh, Nguyen Thi Kim Thuy, Pham Hai Yen, Dan Thuy Hang, Bui Huu Tai, Vivek Bhakta Mathema, Young-Sang Koh, Young Ho Kim

Author information

Phan Van Kiem
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Hoang Le Tuan Anh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Nguyen Xuan Nhiem
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Chau Van Minh
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Nguyen Thi Kim Thuy
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Viettri University of Industry
Pham Hai Yen
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Dan Thuy Hang
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Bui Huu Tai
College of Pharmacy, Chungnam National University
Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
Vivek Bhakta Mathema
School of Medicine and Brain Korea 21 Program, Jeju National Universit
Young-Sang Koh
School of Medicine and Brain Korea 21 Program, Jeju National Universit
Young Ho Kim
College of Pharmacy, Chungnam National University

Keywords: Hedychium coronarium, hedycoronen A, hedycoronen B, tumor necrosis factor-α, interleukin-6, interleukin-12

JOURNAL FREE ACCESS

2012 Volume 60 Issue 2 Pages 246-250

DOI https://doi.org/10.1248/cpb.60.246

Details

Abstract

The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine. From this plant, two new labdanes, 15-methoxylabda-8(17),11E,13-trien-16,15-olide (1) and 16-methoxylabda-8(17),11E,13-trien-15,16-olide (3), named hedycoronens A and B, as well as four known, labda-8(17),11,13-trien-16,15-olide (2), 16-hydroxylabda-8(17),11,13-trien-15,16-olide (4), coronarin A (5), and corronarin E (6) were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. They were evaluated for inhibitory effects on the lipopolysaccharide (LPS)-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1—3 were potent inhibitors of LPS-stimulated interleukin-6 (IL-6) and IL-12 p40, with IC₅₀ ranging from 4.1±0.2 to 9.1±0.3 μM. Compounds 1 and 3 showed moderate inhibitory activity on the tumor necrosis factor-α (TNF-α) production with IC₅₀ values of 46.0±1.3 and 12.7±0.3 μM. The remains of compounds showed inactivity. These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-diterpenes from H. coronarium.

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