Secolignans, Neolignans and Phenylpropanoids from Daphne feddei and Their Biological Activities

Qiu-Fen Hu; Huai-Xue Mu; Hai-Tao Huang; Hua-Ying Lv; Shu-Li Li; Pen-Fei Tu; Gan-Peng Li

doi:10.1248/cpb.59.1421

Notes

Secolignans, Neolignans and Phenylpropanoids from Daphne feddei and Their Biological Activities

Qiu-Fen Hu, Huai-Xue Mu, Hai-Tao Huang, Hua-Ying Lv, Shu-Li Li, Pen-Fei Tu, Gan-Peng Li

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Keywords: Daphne feddei, secolignan, neolignan, anti-human immunodeficiency virus-1 activity, cytotoxicity

JOURNAL FREE ACCESS

2011 Volume 59 Issue 11 Pages 1421-1424

DOI https://doi.org/10.1248/cpb.59.1421

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Abstract

Two new secolignans and one new neolignan, named feddeiphenols A—C (1—3), together with eight known compounds (4—11), were isolated from the leaves and stems of Daphne feddei. Their structures were established on the base of spectroscopic methods, mainly extensive NMR, UV spectroscopy, and MS spectrometry. Compounds 1—11 were tested for their anti-human immunodeficiency virus (HIV)-1 activity and cytotoxicity. The results revealed that compounds 1, 2, 3, 7, and 9 showed therapeutic index (TI) values above 30, respectively, and the other compounds also showed weak anti-HIV-1 activity. Compound 1 showed modest cytotoxic activity. The other compounds also showed weak cytotoxic activity.

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