Flavan-3-ols Having a γ-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro

Dae Sik Jang; Ga Young Lee; Yun Mi Lee; Young Sook Kim; Hang Sun; Dong-Hee Kim; Jin Sook Kim

doi:10.1248/cpb.57.397

Notes

Flavan-3-ols Having a γ-Lactam from the Roots of Actinidia arguta Inhibit the Formation of Advanced Glycation End Products in Vitro

Dae Sik Jang, Ga Young Lee, Yun Mi Lee, Young Sook Kim, Hang Sun, Dong-Hee Kim, Jin Sook Kim

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Keywords: Actinidia arguta, Actinidiaceae, flavan-3-ol, advanced glycation end product, diabetic complication

JOURNAL FREE ACCESS

2009 Volume 57 Issue 4 Pages 397-400

DOI https://doi.org/10.1248/cpb.57.397

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Abstract

Two new flavan-3-ols, 6-(2-pyrrolidinone-5-yl)-(−)-epicatechin (1) and 8-(2-pyrrolidinone-5-yl)-(−)-epicatechin (2), as well as five known compounds, (−)-epicatechin (3), (+)-catechin (4), proanthocyanidin B-4 (5), (+)-pinoresinol, and p-hydroxybenzoic acid, were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structures of compounds 1 and 2 were elucidated by spectroscopic data interpretation, particularly by extensive 1D- and 2D-NMR studies. All the isolates were evaluated in vitro for inhibitory activity on the formation of advanced glycation end products (AGEs). Of these, compounds 1—5 exhibited significant inhibitory activity against AGEs formation with IC₅₀ values ranging from 10.1 to 125.2 μM.

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