One-Step Synthesis and Bioassay of N-Phosphoramidophosphonates

Mudumala Veera Narayana Reddy; Avula Balakrishna; Mungara Anil Kumar; Gangireddygari Chandra Sekhar Reddy; Arigela Uma Ravi Sankar; Cirandur Suresh Reddy; Tirupati Murali Krishna

doi:10.1248/cpb.57.1391

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One-Step Synthesis and Bioassay of N-Phosphoramidophosphonates

Mudumala Veera Narayana Reddy, Avula Balakrishna, Mungara Anil Kumar, Gangireddygari Chandra Sekhar Reddy, Arigela Uma Ravi Sankar, Cirandur Suresh Reddy, Tirupati Murali Krishna

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Keywords: phosphoramidate, tetramethylguanidine, phosphoramidophosphonate, insecticidal activity, antioxidant activity

JOURNAL FREE ACCESS

2009 Volume 57 Issue 12 Pages 1391-1395

DOI https://doi.org/10.1248/cpb.57.1391

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Abstract

A simple one-step synthesis was accomplished for the preparation of N-phosphoramidophosphonates by a direct reaction of phosphoramidate (1) with heterocyclic aldehydes (2a—j) and dialkyl phosphites at 60—70 °C in the presence of tetramethylguanidine. The tetramethylguanidine not only catalyses this reaction but also helps to form pure products in high yields in lesser time. They exhibited good insecticidal and antioxidant properties.

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