Regular Articles
Phosphorylation of Nucleosides and Nucleotides with Inorganic Monoimido-cyclo-Triphosphate
2008 Volume 56 Issue 12 Pages 1698-1703
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2008 Volume 56 Issue 12 Pages 1698-1703
The phosphorylation of nucleosides (adenosine, guanosine, cytidine, and uridine) and nucleotides (adenosine 5′-monophosphate, guanosine 5′-monophosphate, cytidine 5′-monophosphate and uridine 5′-monophosphate) has been achieved using inorganic monoimido-cyclo-triphosphate (MCTP, Na3P3O8NH) in aqueous solution. In this reaction, the 2′-OH or 3′-OH group of the β-D-ribofuranose unit was phosphorylated and the total yield was more than 30% and 14%, respectively. The main products were 2′-diphosphoramidophosphononucleoside and 2′-diphosphoramidophosphononucleoside 5′-monophosphate.
