2006 Volume 54 Issue 8 Pages 1216-1218
Ethyl acetate extract of Pholidota chinensis L. showed strong NO production inhibitory activity in murine macrophage-like cell line, RAW 264.7, which was activated by a lipopolysaccharide (LPS) and interferon-γ (IFN-γ). Fractionation of the active extract led to the isolation of two new stilbene derivatives, 2,3′-dihydroxy-5-methoxy-3,4-methylenedioxydihydrostilbene (Pholidotol A) and 2-hydroxy-5-methoxy-3,4,3′,4′-dimethylenedioxydihydrostilbene (Pholidotol B) together with six known stilbene derivatives. Pholidotols A both B and inhibited Nitric oxide (NO) production with an IC50 value at 24.3 and 17.1 μM, respectively.