Isolation of Peridinin-Related Norcarotenoids with Cell Growth-Inhibitory Activity from the Cultured Dinoflagellate of Symbiodinium sp., a Symbiont of the Okinawan Soft Coral Clavularia viridis, and Analysis of Fatty Acids of the Dinoflagellate

Motoya Suzuki; Kinzo Watanabe; Shoko Fujiwara; Toshie Kurasawa; Takako Wakabayashi; Mikio Tsuzuki; Kazuo Iguchi; Takao Yamori

doi:10.1248/cpb.51.724

Notes

Isolation of Peridinin-Related Norcarotenoids with Cell Growth-Inhibitory Activity from the Cultured Dinoflagellate of Symbiodinium sp., a Symbiont of the Okinawan Soft Coral Clavularia viridis, and Analysis of Fatty Acids of the Dinoflagellate

Motoya Suzuki, Kinzo Watanabe, Shoko Fujiwara, Toshie Kurasawa, Takako Wakabayashi, Mikio Tsuzuki, Kazuo Iguchi, Takao Yamori

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Keywords: dinoflagellate, Symbiodinium sp., carotenoid, growth-inhibitory activity, symbiotic alga, fatty acid

JOURNAL FREE ACCESS

2003 Volume 51 Issue 6 Pages 724-727

DOI https://doi.org/10.1248/cpb.51.724

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Abstract

Two norcarotenoids, 1 and 2, related to peridinin (3) were isolated from the cultured dinoflagellate of the genus Symbiodinium, a symbiont of the Okinawan soft coral Clavularia viridis, which contains in abundance antitumor marine prostanoids such as clavulones. The structures of 1 and 2 were elucidated on the basis of spectroscopic analysis. These compounds showed significant growth-inhibitory activity in vitro toward cancer cells. Analysis of fatty acids of the dinoflagellate was also carried out, suggesting that the marine prostanoids are produced by the host soft coral itself.

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