Prenylated Xanthones from Garcinia xanthochymus

Wisinee Chanmahasathien; Yushan Li; Masayuki Satake; Yasukatsu Oshima; Masami Ishibashi; Nijsiri Ruangrungsi; Yasushi Ohizumi

doi:10.1248/cpb.51.1332

Notes

Prenylated Xanthones from Garcinia xanthochymus

Wisinee Chanmahasathien, Yushan Li, Masayuki Satake, Yasukatsu Oshima, Masami Ishibashi, Nijsiri Ruangrungsi, Yasushi Ohizumi

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Keywords: Garcinia xanthochymus, Guttiferae, xanthone, nerve growth factor (NGF)-potentiating activity, PC12D cell

JOURNAL FREE ACCESS

2003 Volume 51 Issue 11 Pages 1332-1334

DOI https://doi.org/10.1248/cpb.51.1332

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Abstract

A new prenylated xanthone, 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methyl-2-butenyl)xanthone (1), was isolated from the wood of Garcinia xanthochymus together with a known xanthone, garciniaxanthone E (2). Their structures were determined by spectroscopic analysis. Compounds 1 (3 μM) and 2 (10 μM) elicited marked enhancement of nerve growth factor-mediated neurite outgrowth in PC12D cells.

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