Novel Catalytic Asymmetric Sulfoxidation in Water Using the Hypervalent Iodine Reagent Iodoxybenzene

Hirofumi TOHMA; Shinobu TAKIZAWA; Hironori MORIOKA; Tomohiro MAEGAWA; Yasuyuki KITA

doi:10.1248/cpb.48.445

Hirofumi TOHMA, Shinobu TAKIZAWA, Hironori MORIOKA, Tomohiro MAEGAWA, Yasuyuki KITA

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Keywords: asymmetric oxidation, hypervalent iodine reagent, sulfoxide, water

JOURNAL FREE ACCESS

2000 Volume 48 Issue 3 Pages 445-446

DOI https://doi.org/10.1248/cpb.48.445

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Abstract

A ne catalytic asymmetric oxidation of sulfides to sulfoxides in water using the hypervalent iodine(V) reagent iodoxybenzene (PhIO₂) has been developed. This methodology is distinctly different from the previously reported use of cyclodextrins or biological catalysts and provides a new route to asymmetric sulfoxidation in water.

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