Structure Elucidation and Synthesis of a new Bioactive Quinazolone Derivative Obtained from Glycosmis Cf. Chlorosperma

Christoph SEGER; Srunya VAJRODAYA; Harald GREGER; Otmar HOFER

doi:10.1248/cpb.46.1926

Christoph SEGER, Srunya VAJRODAYA, Harald GREGER, Otmar HOFER

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Keywords: Glycosmis, Rutaceae, secondary natural product, quinazolone, synthesis, structure elucidation

JOURNAL FREE ACCESS

1998 Volume 46 Issue 12 Pages 1926-1928

DOI https://doi.org/10.1248/cpb.46.1926

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Abstract

A new quinazolone derivative, (Z)-3, 4-dihydro-3-(2-phenylethenyl)-quinazolin-4-one, was isolated from Glycosmis cf. chlorsperma SPRENG. (Rutaceae). The structure was elucidated on the basis of spectroscopic data and confirmed by comparison with synthetically obtained material. The compound showed bioactivity against different test organisms.

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