Chemical and Pharmaceutical Bulletin
Online ISSN : 1347-5223
Print ISSN : 0009-2363
ISSN-L : 0009-2363
Bioactive Constituents of Chinese Natural Medicines. I. New Sesquiterpene Ketones with Vasorelaxant Effect from Chinese Moxa, the Processed Leaves of Artemisia argyi LEVL. et VANT. : Moxartenone and Moxartenolide
Masayuki YOSHIKAWAHiromi SHIMADAHisashi MATSUDAJohji YAMAHARANobutoshi MURAKAMI
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JOURNAL FREE ACCESS

1996 Volume 44 Issue 9 Pages 1656-1662

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Abstract

Two new sesquiterpene ketones, moxartenone and moxartenolide, and three octadecadienoic acids were isolated from Chinese moxa, the processed leaves of Artemisia argyi LEVL. et VANT., together with two sesquiterpenes, five triterpenes, two phenyl propanoids and three polyoxyflavones. The chamical structures of new sesquiterpenes, moxartenone, moxartenolide, and octadecadienoic acids were determined on the basis of chamical and physicochemical evidence. Moxartenolide was found to inhibit the contractions induced by a high concentration of K+, by norepinephrine, and by serotonin in isolated aortic strips of rat, while moxartenone showed little activity.

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© The Pharmaceutical Society of Japan
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