Syntheses, Immunosuppressive Activity, and Structure-Activity Relationships of Myriocin Analogs, 2-epi-Myriocin, 14-Deoxomyriocin, Z-14-Deoxomyriocin, and Nor-deoxomyriocins

Masayuki YOSHIKAWA; Yoshihiro YOKOKAWA; Yasuhiro OKUNO; Nobuhiro YAGI; Nobutoshi MURAKAMI

doi:10.1248/cpb.43.1647

Masayuki YOSHIKAWA, Yoshihiro YOKOKAWA, Yasuhiro OKUNO, Nobuhiro YAGI, Nobutoshi MURAKAMI

Author information

Keywords: myriocin, 2-epi-myriocin, Z-14-deoxomyriocin, nor-deoxomyriocin, immunosuppressive activity, structure-activity relationship

JOURNAL FREE ACCESS

1995 Volume 43 Issue 10 Pages 1647-1653

DOI https://doi.org/10.1248/cpb.43.1647

Details

Abstract

Nine myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyriocin, and nor-deoxomyriocins, were synthesized from 2-deoxy-D-glucose via common intermediates used in previous myriocin and Z-myriocin syntheses. Immunosuppressive activites of those myriocin analogs on mouse allogeneic mixed lymphocyte reaction were examined, and Z-14-deoxomyriocin was found to show the most potent activity among them. The structure-activity relationships are discussed.

Corresponding author

Register with J-STAGE for free!