Structures of New Indoloditerpenes, Possible Biosynthetic Precursors of the Tremorgenic Mycotoxins, Penitrems, from Penicillium crustosum

Tomoo HOSOE; Koohei NOZAWA; Shun-ichi UDAGAWA; Shoichi NAKAJIMA; Ken-ichi KAWAI

doi:10.1248/cpb.38.3473

Tomoo HOSOE, Koohei NOZAWA, Shun-ichi UDAGAWA, Shoichi NAKAJIMA, Ken-ichi KAWAI

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Keywords: Penicillium crustosum, mycotoxin, indoloditerpene, penitrem A, penitrem B, penitrem C, penitrem D, penitrem E, penitrem F, PC-M5', PC-M6, biosynthetic precursor

JOURNAL FREE ACCESS

1990 Volume 38 Issue 12 Pages 3473-3475

DOI https://doi.org/10.1248/cpb.38.3473

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Abstract

Along with the tremorgenic mycotoxins, penitrems A (3), B (4), D (6), E (7), and F (8), the minor metabolites 1 and 2 were isolated from the mycelia of Penicillium crustosum THOM, which was found contaminating bread intended for school lunches in Tokyo city. The structures of 1 and 2 were determined on the basis of spectroscopic and chemical investigations. these compounds (1 and 2) might be biosynthetic precursors of penitrems.

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