Benzylpiperazine Derivatives. IV. Syntheses and Cerebral Vasodilating Activities of 1-Benzyl-4-diphenylmethyl-piperazine Derivatives

HIROSHI OHTAKA; TOSHIRO KANAZAWA; KEIZO ITO; GORO TSUKAMOTO

doi:10.1248/cpb.35.3270

HIROSHI OHTAKA, TOSHIRO KANAZAWA, KEIZO ITO, GORO TSUKAMOTO

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Keywords: benzylpiperazine, diphenylmethylpiperazine, 1-benzyl-4-diphenylmethylpiperazine, Leuckart-Wallach reaction, cerebral vasodilator, calcium antagonistic activity

JOURNAL FREE ACCESS

1987 Volume 35 Issue 8 Pages 3270-3275

DOI https://doi.org/10.1248/cpb.35.3270

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Abstract

A series of 1-benzyl-4-diphenylmethylpiperazines was prepared and tested for cerebral vasodilating activity. Among the compounds with stronger potency and longer-lasting action than papaverine, the most potent analog 19 (KB-2796) was selected for further study. Some pharmacological properties of 19 are presented.

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