Biological and Pharmaceutical Bulletin
Online ISSN : 1347-5215
Print ISSN : 0918-6158
ISSN-L : 0918-6158
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Manassantin A Isolated from Saururus chinensis Inhibits 5-Lipoxygenase-Dependent Leukotriene C4 Generation by Blocking Mitogen-Activated Protein Kinase Activation in Mast Cells
Su Jeong Kim, Yue Lu, Okyun Kwon, Kyoung Hwangbo, Chang-Seob Seo, Seung Ho Lee, Cheorl-Ho Kim, Young-Chae Chang, Jong Keun Son, Hyeun Wook Chang
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Keywords: Saururus chinensis, manassantin A, 5-lipoxygenase, cytosolic phospholipase A2, mitogen-activated protein kinase, bone marrow-derived mast cell
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2011 Volume 34 Issue 11 Pages 1769-1772

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Abstract

In this study, manassantin A (Man A), an herbal medicine isolated from Saururus chinensis (S. chinensis), markedly inhibited 5-lipoxygenase (5-LO)-dependent leukotriene C4 (LTC4) generation in bone marrow-derived mast cells (BMMCs) in a concentration-dependent manner. To investigate the molecular mechanisms underlying the inhibition of LTC4 generation by Man A, we assessed the effects of Man A on phosphorylation of cytosolic phospholipase A2 (cPLA2) and mitogen-activated protein kinases (MAPKs). Inhibition of LTC4 generation by Man A was accompanied by a decrease in cPLA2 phosphorylation, which occurred via the MAPKs including extracellular signal-regulated protein kinase-1/2 (ERK1/2) as well as p38 and c-Jun N-terminal kinase (JNK) pathways. Taken together, the present study suggests the Man A represents a potential therapeutic approach for the treatment of airway allergic-inflammatory diseases.

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© 2011 The Pharmaceutical Society of Japan
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