Hepatoprotective Effect of Hovenia dulcis THUNB. on Experimental Liver Injuries Induced by Carbon Tetrachloride or D-Galactosamine : Lipopolysaccharide

Koji HASE; Mizue OHSUGI; Quanbo XIONG; Purusotam BASNET; Shigetoshi KADOTA; Tsuneo NAMBA

doi:10.1248/bpb.20.381

Koji HASE, Mizue OHSUGI, Quanbo XIONG, Purusotam BASNET, Shigetoshi KADOTA, Tsuneo NAMBA

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Keywords: Hovenia dulcis, (+)-ampelopsin, hepatoprotective effect, lipopolysaccharide, D-galactosamine, carbon tetrachloride

JOURNAL FREE ACCESS

1997 Volume 20 Issue 4 Pages 381-385

DOI https://doi.org/10.1248/bpb.20.381

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Abstract

The hepatoprotective effects of the fruits of Hovenia dulcis THUNB. on chemically or immunologically induced experimental liver injury models were examined. The methanol extract showed significant hepatoprotective activity against CCl₄-toxicity in rats and D-galactosamine (D-GaIN)/lipopolysaccharide-induced liver injury in mice. The methanol extract also significantly protected against CCl₄-toxicity in primary cultured rat hepatocytes. Hepatoprotective activity-guided fractionation and chemical analysis led to the isolation of an active constituent, (+)-ampelopsin (1) from the methanol extract.

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