N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

Mai Efdi; Kenji Ohguchi; Yukihiro Akao; Yoshinori Nozawa; Mamoru Koketsu; Hideharu Ishihara

doi:10.1248/bpb.30.1972

Notes

N-trans-Feruloyltyramine as a Melanin Biosynthesis Inhibitor

Mai Efdi, Kenji Ohguchi, Yukihiro Akao, Yoshinori Nozawa, Mamoru Koketsu, Hideharu Ishihara

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Keywords: melanin, melanogenesis, tyrosinase

JOURNAL FREE ACCESS

2007 Volume 30 Issue 10 Pages 1972-1974

DOI https://doi.org/10.1248/bpb.30.1972

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Abstract

In this study, we examined the effect of N-trans-feruloyltyramine (FA) on melanogenesis in mouse B16 melanoma cells. Melanogenesis was inhibited by FA in a dose-dependent manner. FA exhibited a greater potency than kojic acid as a standard inhibitor of melanogenesis. Moreover, treatment of B16 melanoma cells with FA was found to cause marked decreases in the expression levels of tyrosinase. FA-induced downregulation of tyrosinase resulted in suppression of melanin biosynthesis in murine B16 melanoma cells.

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