Phosphoinositide Signalling Enzymes in Human T Lymphocytes : Modulation of Phosphoinositidase C Isoform Gamma 1 upon Interferon Treatment

Amelia Cataldi; Rosa Alba Rana; Antonio Caracino; Angela di Baldassarre; Iole Robuffo; Sebastiano Miscia

doi:10.1247/csf.20.143

Amelia Cataldi, Rosa Alba Rana, Antonio Caracino, Angela di Baldassarre, Iole Robuffo, Sebastiano Miscia

Author information

JOURNAL FREE ACCESS

1995 Volume 20 Issue 2 Pages 143-149

DOI https://doi.org/10.1247/csf.20.143

Details

Abstract

In human T lymphocytes immunohlotting analysis of phosphoinositidase C (PIC) isoforms has shown that gamma 1 is the most represented isoform both at the cytoplasmic and nuclear level, and that interferon beta produces, within 90min of treatment, an increase of its expression. These results, also supported by immunoelectronmicroscopic investigation, strongly suggest the involvement of PIC gamma1 in the cascade of molecular events generated by the interaction between interferon and its cell surface receptors.

Corresponding author

Register with J-STAGE for free!