Abstract
Although pectoralis (PECS) blocks are commonly used for breast surgery, recommendations regarding the efficacy of these blocks have thus far not been developed by any professional anesthesia society. Given the potential impact of PECS blocks on analgesia after outpatient breast surgery, The Society for Ambulatory Anesthesia (SAMBA) convened a task force to develop a practice advisory on the use of this analgesic technique. In this practice advisory, we compare the efficacy of PECS blocks with systemic analgesia, local infiltration anesthesia, and paravertebral blockade. Our objectives were to advise on two clinical questions. (1) Does PECS-1 and/or -2 blockade provide more effective analgesia for breast-conserving surgery than either systemic analgesics or surgeon-provided local infiltration anesthesia? (2) Does PECS-1 and/or -2 blockade provide equivalent analgesia for mastectomy compared with a paravertebral block (PVB)? Among patients undergoing breast-conserving surgery, PECS blocks moderately reduce postoperative opioid use, prolong time to analgesic rescue, and decrease postoperative pain scores when compared with systemic analgesics. SAMBA recommends the use of a PECS-1 or -2 blockade in the absence of systemic analgesia (Strength of Recommendation A). No evidence currently exists that strongly favors the use of PECS blocks over surgeon-performed local infiltration in this surgical population. SAMBA cannot recommend PECS blocks over surgical infiltration (Strength of Recommendation C). For patients undergoing a mastectomy, a PECS block may provide an opioid-sparing effect similar to that achieved with PVB; SAMBA recommends the use of a PECS block if a patient is unable to receive a PVB (Strength of Recommendation A).
Similar content being viewed by others
References
Blanco R. The “pecs block”: a novel technique for providing analgesia after breast surgery. Anaesthesia. 2011;66(9):847–8.
Blanco R, Fajardo M, Parras Maldonado T. Ultrasound description of Pecs II (modified Pecs I): a novel approach to breast surgery. Rev Esp Anestesiol Reanim. 2012;59(9):470–5.
Blanco R, Parras T, McDonnell JG, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013;68(11):1107–13.
Jacobs A, Lemoine A, Joshi GP, Van de Velde M, Bonnet F, Collaborators PWG. PROSPECT guideline for oncological breast surgery: a systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia. 2020;75(5):664–73.
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.
Horlocker TT, Birnbach DJ, Connis RT, et al. Practice advisory for the prevention, diagnosis, and management of infectious complications associated with neuraxial techniques: an updated report by the American Society of Anesthesiologists Task Force on Infectious Complications Associated with Neuraxial Techniques and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology. 2017;126(4):585–601.
Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Phys. 2004;69(3):548–56.
Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.
Kim DH, Kim S, Kim CS, et al. Efficacy of pectoral nerve block type II for breast-conserving surgery and sentinel lymph node biopsy: a prospective randomized controlled study. Pain Res Manag. 2018;2018:4315931.
Choi JJ, Jo YY, Kim SH, et al. Remifentanil-sparing effect of pectoral nerve block type ii in breast surgery under surgical pleth index-guided analgesia during total intravenous anesthesia. J Clin Med. 2019;8(8):1181.
Versyck B, van Geffen GJ, Van Houwe P. Prospective double blind randomized placebo-controlled clinical trial of the pectoral nerves (Pecs) block type II. J Clin Anesth. 2017;40:46–50.
De Cassai A, Bonanno C, Sandei L, Finozzi F, Carron M, Marchet A. PECS II block is associated with lower incidence of chronic pain after breast surgery. Korean J Pain. 2019;32(4):286–91.
Abdallah FW, MacLean D, Madjdpour C, Cil T, Bhatia A, Brull R. Pectoralis and serratus fascial plane blocks each provide early analgesic benefits following ambulatory breast cancer surgery: a retrospective propensity-matched cohort study. Anesth Analg. 2017;125(1):294–302.
Jin Z, Li R, Gan TJ, He Y, Lin J. Pectoral nerve (PECs) block for postoperative analgesia-a systematic review and meta-analysis with trial sequential analysis. Int J Physiol Pathophysiol Pharmacol. 2020;12(1):40–50.
Grape S, Jaunin E, El-Boghdadly K, Chan V, Albrecht E. Analgesic efficacy of PECS and serratus plane blocks after breast surgery: a systematic review, meta-analysis and trial sequential analysis. J Clin Anesth. 2020;63:109744.
Versyck B, van Geffen GJ, Chin KJ. Analgesic efficacy of the Pecs II block: a systematic review and meta-analysis. Anaesthesia. 2019;74(5):663–73.
Morioka H, Kamiya Y, Yoshida T, Baba H. Pectoral nerve block combined with general anesthesia for breast cancer surgery: a retrospective comparison. JA Clin Rep. 2015;1(1):15.
Cros J, Senges P, Kaprelian S, et al. Pectoral I block does not improve postoperative analgesia after breast cancer surgery: a randomized, double-blind, dual-centered controlled trial. Reg Anesth Pain Med. 2018;43(6):596–604.
De Cassai A, Bonanno C, Andreatta G, et al. PECS II may reduce chronic pain after breast surgery: a propensity score based secondary analysis of the BREAST trial. J Clin Anesth. 2020;64:109851.
Barrington MJ, Seah GJ, Gotmaker R, Lim D, Byrne K. Quality of recovery after breast surgery: a multicenter randomized clinical trial comparing pectoral nerves interfascial plane (pectoral nerves II) block with surgical infiltration. Anesth Analg. 2020;130(6):1559–67.
Byager N, Hansen MS, Mathiesen O, Dahl JB. The analgesic effect of wound infiltration with local anaesthetics after breast surgery: a qualitative systematic review. Acta Anaesthesiol Scand. 2014;58(4):402–10.
Tam KW, Chen SY, Huang TW, et al. Effect of wound infiltration with ropivacaine or bupivacaine analgesia in breast cancer surgery: a meta-analysis of randomized controlled trials. Int J Surg. 2015;22:79–85.
Tripathy S, Mandal I, Rao PB, Panda A, Mishra T, Kar M. Opioid-free anesthesia for breast cancer surgery: a comparison of ultrasound guided paravertebral and pectoral nerve blocks. A randomized controlled trial. J Anaesthesiol Clin Pharmacol. 2019;35(4):475–80.
Kulhari S, Bharti N, Bala I, Arora S, Singh G. Efficacy of pectoral nerve block versus thoracic paravertebral block for postoperative analgesia after radical mastectomy: a randomized controlled trial. Br J Anaesth. 2016;117(3):382–6.
Siddeshwara A, Singariya G, Kamal M, Kumari K, Seervi S, Kumar R. Comparison of efficacy of ultrasound-guided pectoral nerve block versus thoracic paravertebral block using levobupivacaine and dexamethasone for postoperative analgesia after modified radical mastectomy: a randomized controlled trial. Saudi J Anaesth. 2019;13(4):325–31.
Martsiniv VV, Loskutov AO, Strokan MA, Pylypenko MM, Bondar VM. Efficacy of pectoral nerve block type II versus thoracic paravertebral block for analgesia in breast cancer surgery. Klin Onkol. 2020;33(4):296–301.
Singh PMBA, Trikha A. Opioid-sparing effects of the thoracic interfascial plane blocks: a meta-analysis of randomized controlled trials. Saudi J Anesth. 2018;12(1):103–11.
Jin Z, Durrands T, Li R, Gan TJ, Lin J. Pectoral block versus paravertebral block: a systematic review, meta-analysis and trial sequential analysis. Reg Anesth Pain Med. 2020;45(9):727–32.
Wahba SS, Kamal SM. Thoracic paravertebral block versus pectoral nerve block for analgesia after breast surgery. Egypt J Anaesth. 2014;30(2):129–35.
Munoz-Leyva F, El-Boghdadly K, Chan V. Is the minimal clinically important difference (MCID) in acute pain a good measure of analgesic efficacy in regional anesthesia? Reg Anesth Pain Med. 2020;45(12):1000–5.
Grape S, El-Boghdadly K, Albrecht E. Analgesic efficacy of PECS vs paravertebral blocks after radical mastectomy: a systematic review, meta-analysis and trial sequential analysis. J Clin Anesth. 2020;63:109745.
Kairaluoma PM, Bachmann MS, Rosenberg PH, Pere PJ. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesth Analg. 2006;103(3):703–8.
Albi-Feldzer A, Dureau S, Ghimouz A, et al. Preoperative paravertebral block and chronic pain after breast cancer surgery: a double-blind randomized trial. Anesthesiology. 2021;135(6):1091–103.
Harkouk H, Fletcher D, Martinez V. Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery. Reg Anesth Pain Med. 2021;46(3):251–7.
Hussain N, Shastri U, McCartney CJL, et al. Should thoracic paravertebral blocks be used to prevent chronic postsurgical pain after breast cancer surgery? A systematic analysis of evidence in light of IMMPACT recommendations. Pain. 2018;159(10):1955–71.
Asaad M, Bailey C, Boukovalas S, et al. Self-reported risk factors for financial distress and attitudes regarding cost discussions in cancer care: a single-institution cross-sectional pilot study of breast reconstruction recipients. Plast Reconstr Surg. 2021;147(4):587e–95e.
Hall-Burton DM, Hudson ME, Grudziak JS, Cunningham S, Boretsky K, Boretsky KR. Regional anesthesia is cost-effective in preventing unanticipated hospital admission in pediatric patients having anterior cruciate ligament reconstruction. Reg Anesth Pain Med. 2016;41(4):527–31.
Ackerman RS, Hirschi M, Alford B, Evans T, Kiluk JV, Patel SY. Enhanced REVENUE after surgery? A cost-standardized enhanced recovery pathway for mastectomy decreases length of stay. World J Surg. 2019;43(3):839–45.
Bashandy GM, Abbas DN. Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial. Reg Anesth Pain Med. 2015;40(1):68–74.
Bell A, Ali O, Robinson A, et al. The role of pectoral nerve blocks in a day-case mastectomy service: a prospective cohort study. Ann Med Surg (Lond). 2019;48:65–8.
Offodile AC 2nd, Sheckter CC, Tucker A, et al. Preoperative paravertebral blocks for the management of acute pain following mastectomy: a cost-effectiveness analysis. Breast Cancer Res Treat. 2017;165(3):477–84.
Stein MJ, Arnaout A, Thavorn K, Van Katwyk S, Zhang J. A cost effectiveness analysis of paravertebral blocks in immediate breast reconstruction following mastectomy. J Plast Reconstr Aesthet Surg. 2019;72(7):1219–43.
Klein SM, Bergh A, Steele SM, Georgiade GS, Greengrass RA. Thoracic paravertebral block for breast surgery. Anesth Analg. 2000;90(6):1402–5.
Das S, Bhattacharya P, Mandal MC, Mukhopadhyay S, Basu SR, Mandol BK. Multiple-injection thoracic paravertebral block as an alternative to general anaesthesia for elective breast surgeries: a randomised controlled trial. Indian J Anaesth. 2012;56(1):27–33.
Fallatah S, Mousa WF. Multiple levels paravertebral block versus morphine patient-controlled analgesia for postoperative analgesia following breast cancer surgery with unilateral lumpectomy, and axillary lymph nodes dissection. Saudi J Anaesth. 2016;10(1):13–7.
Kasimahanti R, Arora S, Bhatia N, Singh G. Ultrasound-guided single- versus double-level thoracic paravertebral block for postoperative analgesia in total mastectomy with axillary clearance. J Clin Anesth. 2016;33:414–21.
Black ND, Stecco C, Chan VWS. Fascial plane blocks: more questions than answers? Anesth Analg. 2021;132(3):899–905.
Stoving K, Rothe C, Rosenstock CV, Aasvang EK, Lundstrom LH, Lange KH. Cutaneous sensory block area, muscle-relaxing effect, and block duration of the transversus abdominis plane block: a randomized, blinded, and placebo-controlled study in healthy volunteers. Reg Anesth Pain Med. 2015;40(4):355–62.
Ardon AE, Lee J, Franco CD, Riutort KT, Greengrass RA. Paravertebral block: anatomy and relevant safety issues. Korean J Anesthesiol. 2020;73(5):394–400.
Funding
No sources of funding were used to assist in the preparation of this article.
Author information
Authors and Affiliations
Contributions
AEA, SHW, and RAG helped formulate the systematic review strategy, contributed to the literature search, reviewed articles, and helped write and edit the manuscript. JEG III, KG, and MSS helped with the literature search, reviewed articles, and helped write the manuscript. MJO’R and HKT helped with the literature search, reviewed articles, and helped write and edit the manuscript. T-AM, IL, and SMcL reviewed articles and helped edit the manuscript. All authors reviewed and approved the final manuscript.
Corresponding author
Ethics declarations
Disclosures
Alberto E. Ardon, John E. George III, Kapil Gupta, Michael J. O’Rourke, Melinda S. Seering, Hanae K. Tokita, Sylvia H. Wilson, Tracy-Ann Moo, Ingrid Lizarraga, Sarah McLaughlin, and Roy A. Greengrass have no conflicts of interest to declare.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Supplementary Information
Below is the link to the electronic supplementary material.
Rights and permissions
About this article
Cite this article
Ardon, A.E., George, J.E., Gupta, K. et al. The Use of Pectoralis Blocks in Breast Surgery: A Practice Advisory and Narrative Review from the Society for Ambulatory Anesthesia (SAMBA). Ann Surg Oncol 29, 4777–4786 (2022). https://doi.org/10.1245/s10434-022-11724-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1245/s10434-022-11724-9