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The Use of Pectoralis Blocks in Breast Surgery: A Practice Advisory and Narrative Review from the Society for Ambulatory Anesthesia (SAMBA)

  • Breast Oncology
  • Published:
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Abstract

Although pectoralis (PECS) blocks are commonly used for breast surgery, recommendations regarding the efficacy of these blocks have thus far not been developed by any professional anesthesia society. Given the potential impact of PECS blocks on analgesia after outpatient breast surgery, The Society for Ambulatory Anesthesia (SAMBA) convened a task force to develop a practice advisory on the use of this analgesic technique. In this practice advisory, we compare the efficacy of PECS blocks with systemic analgesia, local infiltration anesthesia, and paravertebral blockade. Our objectives were to advise on two clinical questions. (1) Does PECS-1 and/or -2 blockade provide more effective analgesia for breast-conserving surgery than either systemic analgesics or surgeon-provided local infiltration anesthesia? (2) Does PECS-1 and/or -2 blockade provide equivalent analgesia for mastectomy compared with a paravertebral block (PVB)? Among patients undergoing breast-conserving surgery, PECS blocks moderately reduce postoperative opioid use, prolong time to analgesic rescue, and decrease postoperative pain scores when compared with systemic analgesics. SAMBA recommends the use of a PECS-1 or -2 blockade in the absence of systemic analgesia (Strength of Recommendation A). No evidence currently exists that strongly favors the use of PECS blocks over surgeon-performed local infiltration in this surgical population. SAMBA cannot recommend PECS blocks over surgical infiltration (Strength of Recommendation C). For patients undergoing a mastectomy, a PECS block may provide an opioid-sparing effect similar to that achieved with PVB; SAMBA recommends the use of a PECS block if a patient is unable to receive a PVB (Strength of Recommendation A).

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References

  1. Blanco R. The “pecs block”: a novel technique for providing analgesia after breast surgery. Anaesthesia. 2011;66(9):847–8.

    Article  CAS  PubMed  Google Scholar 

  2. Blanco R, Fajardo M, Parras Maldonado T. Ultrasound description of Pecs II (modified Pecs I): a novel approach to breast surgery. Rev Esp Anestesiol Reanim. 2012;59(9):470–5.

    Article  CAS  PubMed  Google Scholar 

  3. Blanco R, Parras T, McDonnell JG, Prats-Galino A. Serratus plane block: a novel ultrasound-guided thoracic wall nerve block. Anaesthesia. 2013;68(11):1107–13.

    Article  CAS  PubMed  Google Scholar 

  4. Jacobs A, Lemoine A, Joshi GP, Van de Velde M, Bonnet F, Collaborators PWG. PROSPECT guideline for oncological breast surgery: a systematic review and procedure-specific postoperative pain management recommendations. Anaesthesia. 2020;75(5):664–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

    Article  PubMed  PubMed Central  Google Scholar 

  6. Horlocker TT, Birnbach DJ, Connis RT, et al. Practice advisory for the prevention, diagnosis, and management of infectious complications associated with neuraxial techniques: an updated report by the American Society of Anesthesiologists Task Force on Infectious Complications Associated with Neuraxial Techniques and the American Society of Regional Anesthesia and Pain Medicine. Anesthesiology. 2017;126(4):585–601.

    Article  Google Scholar 

  7. Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. Am Fam Phys. 2004;69(3):548–56.

    Google Scholar 

  8. Higgins JP, Altman DG, Gotzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.

    Article  PubMed  PubMed Central  Google Scholar 

  9. Kim DH, Kim S, Kim CS, et al. Efficacy of pectoral nerve block type II for breast-conserving surgery and sentinel lymph node biopsy: a prospective randomized controlled study. Pain Res Manag. 2018;2018:4315931.

    PubMed  PubMed Central  Google Scholar 

  10. Choi JJ, Jo YY, Kim SH, et al. Remifentanil-sparing effect of pectoral nerve block type ii in breast surgery under surgical pleth index-guided analgesia during total intravenous anesthesia. J Clin Med. 2019;8(8):1181.

    Article  PubMed Central  CAS  Google Scholar 

  11. Versyck B, van Geffen GJ, Van Houwe P. Prospective double blind randomized placebo-controlled clinical trial of the pectoral nerves (Pecs) block type II. J Clin Anesth. 2017;40:46–50.

    Article  CAS  PubMed  Google Scholar 

  12. De Cassai A, Bonanno C, Sandei L, Finozzi F, Carron M, Marchet A. PECS II block is associated with lower incidence of chronic pain after breast surgery. Korean J Pain. 2019;32(4):286–91.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. Abdallah FW, MacLean D, Madjdpour C, Cil T, Bhatia A, Brull R. Pectoralis and serratus fascial plane blocks each provide early analgesic benefits following ambulatory breast cancer surgery: a retrospective propensity-matched cohort study. Anesth Analg. 2017;125(1):294–302.

    Article  PubMed  Google Scholar 

  14. Jin Z, Li R, Gan TJ, He Y, Lin J. Pectoral nerve (PECs) block for postoperative analgesia-a systematic review and meta-analysis with trial sequential analysis. Int J Physiol Pathophysiol Pharmacol. 2020;12(1):40–50.

    PubMed  PubMed Central  Google Scholar 

  15. Grape S, Jaunin E, El-Boghdadly K, Chan V, Albrecht E. Analgesic efficacy of PECS and serratus plane blocks after breast surgery: a systematic review, meta-analysis and trial sequential analysis. J Clin Anesth. 2020;63:109744.

    Article  PubMed  Google Scholar 

  16. Versyck B, van Geffen GJ, Chin KJ. Analgesic efficacy of the Pecs II block: a systematic review and meta-analysis. Anaesthesia. 2019;74(5):663–73.

    Article  CAS  PubMed  Google Scholar 

  17. Morioka H, Kamiya Y, Yoshida T, Baba H. Pectoral nerve block combined with general anesthesia for breast cancer surgery: a retrospective comparison. JA Clin Rep. 2015;1(1):15.

    Article  PubMed  Google Scholar 

  18. Cros J, Senges P, Kaprelian S, et al. Pectoral I block does not improve postoperative analgesia after breast cancer surgery: a randomized, double-blind, dual-centered controlled trial. Reg Anesth Pain Med. 2018;43(6):596–604.

    Article  PubMed  Google Scholar 

  19. De Cassai A, Bonanno C, Andreatta G, et al. PECS II may reduce chronic pain after breast surgery: a propensity score based secondary analysis of the BREAST trial. J Clin Anesth. 2020;64:109851.

    Article  PubMed  Google Scholar 

  20. Barrington MJ, Seah GJ, Gotmaker R, Lim D, Byrne K. Quality of recovery after breast surgery: a multicenter randomized clinical trial comparing pectoral nerves interfascial plane (pectoral nerves II) block with surgical infiltration. Anesth Analg. 2020;130(6):1559–67.

    Article  CAS  PubMed  Google Scholar 

  21. Byager N, Hansen MS, Mathiesen O, Dahl JB. The analgesic effect of wound infiltration with local anaesthetics after breast surgery: a qualitative systematic review. Acta Anaesthesiol Scand. 2014;58(4):402–10.

    Article  CAS  PubMed  Google Scholar 

  22. Tam KW, Chen SY, Huang TW, et al. Effect of wound infiltration with ropivacaine or bupivacaine analgesia in breast cancer surgery: a meta-analysis of randomized controlled trials. Int J Surg. 2015;22:79–85.

    Article  PubMed  Google Scholar 

  23. Tripathy S, Mandal I, Rao PB, Panda A, Mishra T, Kar M. Opioid-free anesthesia for breast cancer surgery: a comparison of ultrasound guided paravertebral and pectoral nerve blocks. A randomized controlled trial. J Anaesthesiol Clin Pharmacol. 2019;35(4):475–80.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Kulhari S, Bharti N, Bala I, Arora S, Singh G. Efficacy of pectoral nerve block versus thoracic paravertebral block for postoperative analgesia after radical mastectomy: a randomized controlled trial. Br J Anaesth. 2016;117(3):382–6.

    Article  CAS  PubMed  Google Scholar 

  25. Siddeshwara A, Singariya G, Kamal M, Kumari K, Seervi S, Kumar R. Comparison of efficacy of ultrasound-guided pectoral nerve block versus thoracic paravertebral block using levobupivacaine and dexamethasone for postoperative analgesia after modified radical mastectomy: a randomized controlled trial. Saudi J Anaesth. 2019;13(4):325–31.

    Article  PubMed  PubMed Central  Google Scholar 

  26. Martsiniv VV, Loskutov AO, Strokan MA, Pylypenko MM, Bondar VM. Efficacy of pectoral nerve block type II versus thoracic paravertebral block for analgesia in breast cancer surgery. Klin Onkol. 2020;33(4):296–301.

    Article  PubMed  Google Scholar 

  27. Singh PMBA, Trikha A. Opioid-sparing effects of the thoracic interfascial plane blocks: a meta-analysis of randomized controlled trials. Saudi J Anesth. 2018;12(1):103–11.

    Article  Google Scholar 

  28. Jin Z, Durrands T, Li R, Gan TJ, Lin J. Pectoral block versus paravertebral block: a systematic review, meta-analysis and trial sequential analysis. Reg Anesth Pain Med. 2020;45(9):727–32.

    Article  PubMed  Google Scholar 

  29. Wahba SS, Kamal SM. Thoracic paravertebral block versus pectoral nerve block for analgesia after breast surgery. Egypt J Anaesth. 2014;30(2):129–35.

    Article  Google Scholar 

  30. Munoz-Leyva F, El-Boghdadly K, Chan V. Is the minimal clinically important difference (MCID) in acute pain a good measure of analgesic efficacy in regional anesthesia? Reg Anesth Pain Med. 2020;45(12):1000–5.

    Article  PubMed  Google Scholar 

  31. Grape S, El-Boghdadly K, Albrecht E. Analgesic efficacy of PECS vs paravertebral blocks after radical mastectomy: a systematic review, meta-analysis and trial sequential analysis. J Clin Anesth. 2020;63:109745.

    Article  PubMed  Google Scholar 

  32. Kairaluoma PM, Bachmann MS, Rosenberg PH, Pere PJ. Preincisional paravertebral block reduces the prevalence of chronic pain after breast surgery. Anesth Analg. 2006;103(3):703–8.

    Article  PubMed  Google Scholar 

  33. Albi-Feldzer A, Dureau S, Ghimouz A, et al. Preoperative paravertebral block and chronic pain after breast cancer surgery: a double-blind randomized trial. Anesthesiology. 2021;135(6):1091–103.

    Article  CAS  PubMed  Google Scholar 

  34. Harkouk H, Fletcher D, Martinez V. Paravertebral block for the prevention of chronic postsurgical pain after breast cancer surgery. Reg Anesth Pain Med. 2021;46(3):251–7.

    Article  PubMed  Google Scholar 

  35. Hussain N, Shastri U, McCartney CJL, et al. Should thoracic paravertebral blocks be used to prevent chronic postsurgical pain after breast cancer surgery? A systematic analysis of evidence in light of IMMPACT recommendations. Pain. 2018;159(10):1955–71.

    Article  PubMed  Google Scholar 

  36. Asaad M, Bailey C, Boukovalas S, et al. Self-reported risk factors for financial distress and attitudes regarding cost discussions in cancer care: a single-institution cross-sectional pilot study of breast reconstruction recipients. Plast Reconstr Surg. 2021;147(4):587e–95e.

    Article  CAS  PubMed  Google Scholar 

  37. Hall-Burton DM, Hudson ME, Grudziak JS, Cunningham S, Boretsky K, Boretsky KR. Regional anesthesia is cost-effective in preventing unanticipated hospital admission in pediatric patients having anterior cruciate ligament reconstruction. Reg Anesth Pain Med. 2016;41(4):527–31.

    Article  CAS  PubMed  Google Scholar 

  38. Ackerman RS, Hirschi M, Alford B, Evans T, Kiluk JV, Patel SY. Enhanced REVENUE after surgery? A cost-standardized enhanced recovery pathway for mastectomy decreases length of stay. World J Surg. 2019;43(3):839–45.

    Article  PubMed  Google Scholar 

  39. Bashandy GM, Abbas DN. Pectoral nerves I and II blocks in multimodal analgesia for breast cancer surgery: a randomized clinical trial. Reg Anesth Pain Med. 2015;40(1):68–74.

    Article  CAS  PubMed  Google Scholar 

  40. Bell A, Ali O, Robinson A, et al. The role of pectoral nerve blocks in a day-case mastectomy service: a prospective cohort study. Ann Med Surg (Lond). 2019;48:65–8.

    Article  PubMed  PubMed Central  Google Scholar 

  41. Offodile AC 2nd, Sheckter CC, Tucker A, et al. Preoperative paravertebral blocks for the management of acute pain following mastectomy: a cost-effectiveness analysis. Breast Cancer Res Treat. 2017;165(3):477–84.

    Article  PubMed  Google Scholar 

  42. Stein MJ, Arnaout A, Thavorn K, Van Katwyk S, Zhang J. A cost effectiveness analysis of paravertebral blocks in immediate breast reconstruction following mastectomy. J Plast Reconstr Aesthet Surg. 2019;72(7):1219–43.

    Article  PubMed  Google Scholar 

  43. Klein SM, Bergh A, Steele SM, Georgiade GS, Greengrass RA. Thoracic paravertebral block for breast surgery. Anesth Analg. 2000;90(6):1402–5.

    Article  CAS  PubMed  Google Scholar 

  44. Das S, Bhattacharya P, Mandal MC, Mukhopadhyay S, Basu SR, Mandol BK. Multiple-injection thoracic paravertebral block as an alternative to general anaesthesia for elective breast surgeries: a randomised controlled trial. Indian J Anaesth. 2012;56(1):27–33.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  45. Fallatah S, Mousa WF. Multiple levels paravertebral block versus morphine patient-controlled analgesia for postoperative analgesia following breast cancer surgery with unilateral lumpectomy, and axillary lymph nodes dissection. Saudi J Anaesth. 2016;10(1):13–7.

    Article  PubMed  PubMed Central  Google Scholar 

  46. Kasimahanti R, Arora S, Bhatia N, Singh G. Ultrasound-guided single- versus double-level thoracic paravertebral block for postoperative analgesia in total mastectomy with axillary clearance. J Clin Anesth. 2016;33:414–21.

    Article  PubMed  Google Scholar 

  47. Black ND, Stecco C, Chan VWS. Fascial plane blocks: more questions than answers? Anesth Analg. 2021;132(3):899–905.

    Article  PubMed  Google Scholar 

  48. Stoving K, Rothe C, Rosenstock CV, Aasvang EK, Lundstrom LH, Lange KH. Cutaneous sensory block area, muscle-relaxing effect, and block duration of the transversus abdominis plane block: a randomized, blinded, and placebo-controlled study in healthy volunteers. Reg Anesth Pain Med. 2015;40(4):355–62.

    Article  CAS  PubMed  Google Scholar 

  49. Ardon AE, Lee J, Franco CD, Riutort KT, Greengrass RA. Paravertebral block: anatomy and relevant safety issues. Korean J Anesthesiol. 2020;73(5):394–400.

    Article  PubMed  PubMed Central  Google Scholar 

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Contributions

AEA, SHW, and RAG helped formulate the systematic review strategy, contributed to the literature search, reviewed articles, and helped write and edit the manuscript. JEG III, KG, and MSS helped with the literature search, reviewed articles, and helped write the manuscript. MJO’R and HKT helped with the literature search, reviewed articles, and helped write and edit the manuscript. T-AM, IL, and SMcL reviewed articles and helped edit the manuscript. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to Alberto E. Ardon MD, MPH.

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Disclosures

Alberto E. Ardon, John E. George III, Kapil Gupta, Michael J. O’Rourke, Melinda S. Seering, Hanae K. Tokita, Sylvia H. Wilson, Tracy-Ann Moo, Ingrid Lizarraga, Sarah McLaughlin, and Roy A. Greengrass have no conflicts of interest to declare.

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Ardon, A.E., George, J.E., Gupta, K. et al. The Use of Pectoralis Blocks in Breast Surgery: A Practice Advisory and Narrative Review from the Society for Ambulatory Anesthesia (SAMBA). Ann Surg Oncol 29, 4777–4786 (2022). https://doi.org/10.1245/s10434-022-11724-9

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  • DOI: https://doi.org/10.1245/s10434-022-11724-9

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