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ASO Author Reflections: Revision Surgery or Timely Chemotherapy for Incidental Gallbladder Cancers: What is Actually Helping?

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Abstract

Revision surgery with or without chemotherapy in the neoadjuvant or adjuvant setting remains the standard treatment for incidental gallbladder cancers (iGBCs). Over the years, researchers have retrospectively analyzed the surgical audits and tried to establish the perceived benefit and optimal timing for revision surgery. Patkar and colleagues have analyzed the outcomes for 517 patients with iGBC, concluding that there is no optimal timing for performing a revision surgery after initial cholecystectomy. Revision surgery is essentially the most accurate staging procedure and should be offered to patients at any time of presentation if they remain non-metastatic. Timely initiation of chemotherapy is the key to improving the outcomes for patients with this otherwise inherently aggressive disease.

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References

  1. Goel M, Tamhankar A, Rangarajan V, Patkar S, Ramadwar M, Shrikhande SV. Role of PET CT scan in redefining treatment of incidental gall bladder carcinoma: PET scan in incidental gallbladder carcinoma. J Surg Oncol. 2016;113:652–8.

    Article  Google Scholar 

  2. Fuks D, Regimbeau JM, Le Treut Y-P, Bachellier P, Raventos A, Pruvot F-R, et al. Incidental gallbladder cancer by the AFC-GBC-2009 Study Group. World J Surg. 2011;35:1887–97.

    Article  Google Scholar 

  3. Patkar S, Patel S, Gupta A, Ramaswamy A, Ostwal V, Goel M, et al. Revision surgery for incidental gallbladder cancer: challenging the dogma: ideal timing and real world applicability. Ann Surg Oncol. https://doi.org/10.1245/s10434-021-09687-4.

  4. de Savornin Lohman EAJ, van der Geest LG, de Bitter TJJ, Nagtegaal ID, van Laarhoven CJHM, van den Boezem P, et al. Re-resection in incidental gallbladder cancer: survival and the incidence of residual disease. Ann Surg Oncol. 2020;27:1132–42.

    Article  Google Scholar 

  5. Goetze TO, Bechstein WO, Bankstahl US, Keck T, Königsrainer A, Lang SA, et al. Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC): a phase III study of the German registry of incidental gallbladder carcinoma platform (GR): the AIO/ CALGP/ ACO- GAIN-trial. BMC Cancer. 2020;20:122.

    Article  CAS  Google Scholar 

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Correspondence to Mahesh Goel MS.

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Patkar, S., Patel, S. & Goel, M. ASO Author Reflections: Revision Surgery or Timely Chemotherapy for Incidental Gallbladder Cancers: What is Actually Helping?. Ann Surg Oncol 28, 6767–6768 (2021). https://doi.org/10.1245/s10434-021-09702-8

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  • DOI: https://doi.org/10.1245/s10434-021-09702-8

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