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Enteral Feeding Access Has an Impact on Outcomes for Patients with Esophageal Cancer Undergoing Esophagectomy: An Analysis of SEER-Medicare

  • Thoracic Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Optimal nutrition after esophagectomy is challenging due to alterations in eating, both from the tumor and during surgical recovery. Enteral nutrition via feeding tube is commonly used. The impact of feeding tubes on post-esophagectomy outcomes was examined in a large national data set.

Methods

Patients with esophageal cancer (1998–2013) undergoing esophagectomy were extracted from the Surveillance Epidemiology and End Results-Medicare database. Chi-square and t tests were used to compare categorical and continuous variables. Time trend analyses were performed with Cochran–Armitage survival using log-rank and multivariable analysis with generalized linear modeling.

Results

The study examined 2495 patients. The majority had enteral feeding access (71%, n = 1794) during the perioperative period. Mortality among the patients with feeding tubes was lower at 30 days (5.4% vs 8.4%), 60 days (9.0% vs 13.0%), and 90 days (12.2% vs 15.8%). In the multivariable analysis, the patients with feeding tubes had improved short-term survival at 30 days (odds ratio [OR], 0.65, 95% confidence interval [CI], 0.46–0.93), 60 days (OR, 0.64; 95% CI, 0.49–0.85), and 90 days (OR, 0.70; 95% CI, 0.54–0.90). The hospital stay was shorter for the patients undergoing enteral feeding tube placement (17.9 vs 19.5 days; p = 0.04). Discharge destination (home vs health care facility) showed no difference.

Conclusions

Feeding tubes in patients undergoing esophagectomy were associated with an increase in short-term survival up to 90 days after surgery. Feeding tube placement was not associated with higher rates of non-home discharges and did not prolong the hospital stay.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Carolinas Medical Center, Levine Cancer Institute, Charlotte, NC, USA

    Patrick D. Lorimer MD, Benjamin M. Motz MD, Michael Watson MD, Joshua S. Hill MD & Jonathan C. Salo MD, FACS

  2. Department of Biostatistics, Carolinas Medical Center, Levine Cancer Institute, Charlotte, NC, USA

    Sally J. Trufan MS

  3. Southeast Radiation Oncology, Charlotte, NC, USA

    Roshan S. Prabhu MD

Authors
  1. Patrick D. Lorimer MD
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  2. Benjamin M. Motz MD
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  3. Michael Watson MD
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  6. Joshua S. Hill MD
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  7. Jonathan C. Salo MD, FACS
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Correspondence to Jonathan C. Salo MD, FACS.

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Lorimer, P.D., Motz, B.M., Watson, M. et al. Enteral Feeding Access Has an Impact on Outcomes for Patients with Esophageal Cancer Undergoing Esophagectomy: An Analysis of SEER-Medicare. Ann Surg Oncol 26, 1311–1319 (2019). https://doi.org/10.1245/s10434-019-07230-0

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  • DOI: https://doi.org/10.1245/s10434-019-07230-0

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