Abstract
Background
Inactivating mutation and consequent expression loss of stromal antigen 2 (STAG2, also known as SA2), a component of the cohesion complex, is one of the most common genetic aberrations in urothelial carcinoma. However, the clinicopathologic or prognostic significance of STAG2 alterations in upper tract urothelial carcinoma (UTUC) is largely unknown.
Methods
This study immunohistochemically examined the expression of STAG2 in 171 patients with UTUC. The correlations of STAG2 loss with clinicopathologic features and patients’ prognoses were examined.
Results
Loss of STAG2 expression was observed in 28 cases (16%). Loss of STAG2 was significantly correlated with histological low grade, papillary architecture, noninvasive tumors, absence of concomitant carcinoma in situ, and lower Ki-67 expression. Loss of STAG2 alone was not significantly associated with patients’ prognoses in either the uni- or multivariate analysis. However, STAG2 loss was significantly associated with worse clinical outcome in UTUC with high Ki-67 proliferation indexes, but not in UTUC with low Ki-67 expression.
Conclusions
Loss of STAG2 was generally associated with less aggressive features in UTUC. However, the STAG2 loss was an ominous sign in the subpopulation with higher Ki-67 proliferation indexes. Examining both STAG2 and Ki-67 status may be useful for identifying aggressive clinical behavior of UTUC.
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Acknowledgment
We are grateful to Harumi Yamamura and Kei Sakuma for their excellent technical support.
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10434_2017_6097_MOESM1_ESM.tif
Supplementary Fig. 1. Kaplan–Meier curves of metastasis-free survival according to STAG2 status in p53 negative group (A) and p53 positive group (B) and cancer-specific survival in p53 negative group (C) and p53 positive group (D) in 171 upper tract urothelial carcinoma patients after nephroureterectomy. Supplementary material 1 (TIFF 2033 kb)
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Miyakawa, J., Morikawa, T., Miyama, Y. et al. Loss of Stromal Antigen 2 (STAG2) Expression in Upper Urinary Tract Carcinoma: Differential Prognostic Effect According to the Ki-67 Proliferating Index. Ann Surg Oncol 24, 4059–4066 (2017). https://doi.org/10.1245/s10434-017-6097-7
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DOI: https://doi.org/10.1245/s10434-017-6097-7