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Management of Local Recurrence of Pediatric Osteosarcoma Following Limb-Sparing Surgery

  • Bone and Soft Tissue Sarcomas
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

The optimal management of locally recurrent pediatric osteosarcoma is not established, especially after prior limb-sparing surgery. We describe our experience in the management of these patients and identify prognostic indicators of post-recurrence survival.

Methods

We conducted a retrospective, single-institution review of patients with locally recurrent osteosarcoma after limb-salvage surgery who were treated between October 1989 and January 2012. The management of each recurrence was evaluated, and patient, disease, and treatment factors were correlated with post-recurrence survival (PRS).

Results

Of 200 patients who underwent limb-sparing procedures, 18 (9 %) had biopsy-proven local recurrence. Recurrences occurred in soft tissue in 15 patients (83.3 %). Six patients (33.3 %) were amenable to repeat limb-sparing surgery. Median time to local recurrence was 1.4 (range 0.6–10.4) years. Median PRS was 11.8 months (range 3.7 months–12.1 years). Post-recurrence survival was significantly associated with the length of resection margins and was longer when recurrent tumors were resected with margins of ≥1 cm, compared with subcentimeter or positive margins (P = 0.03). Median PRS was longer in patients who underwent amputations (2.44 years) than those who underwent repeat limb-sparing surgery (0.86 years), and in patients who had distant metastases resected (2.7 years) than those who did not (0.85 years); however, differences were not significant.

Conclusions

Local management of recurrent osteosarcoma in a previously reconstructed limb is highly individualized. A sufficiently wide resection is important for local control of recurrences, independent of the type of surgery. Maintaining control of distant metastases may also contribute to improved survival.

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Acknowledgment

The authors thank Ms. Liza Emanus, Department of Surgery, for administrative assistance, and Ms. Betsy Williford, Biomedical Communications, for preparing figures. This work was supported in part by the National Cancer Institute [Cancer Center Support (CORE) grant numbers CA-21765 and CA-23099]; and the American Lebanese Syrian Associated Charities.

Disclosure

The authors have declared no conflicts of interest.

Author information

Authors and Affiliations

  1. Department of Surgery, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Amos H. P. Loh MD, Michael D. Neel MD & Bhaskar N. Rao MD

  2. Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Fariba Navid MD

  3. Department of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA

    Fariba Navid MD

  4. Department of Biostatistics, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Chong Wang MA & Jianrong Wu PhD

  5. Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Armita Bahrami MD

Authors
  1. Amos H. P. Loh MD
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  2. Fariba Navid MD
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  3. Chong Wang MA
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  4. Armita Bahrami MD
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  5. Jianrong Wu PhD
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  6. Michael D. Neel MD
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  7. Bhaskar N. Rao MD
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Correspondence to Amos H. P. Loh MD.

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Loh, A.H.P., Navid, F., Wang, C. et al. Management of Local Recurrence of Pediatric Osteosarcoma Following Limb-Sparing Surgery. Ann Surg Oncol 21, 1948–1955 (2014). https://doi.org/10.1245/s10434-014-3550-8

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  • DOI: https://doi.org/10.1245/s10434-014-3550-8

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