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Feasibility of Accelerated Partial Breast Irradiation in a Large Inner-City Public Hospital

  • Breast Oncology
  • Published:
Annals of Surgical Oncology Aims and scope Submit manuscript

Abstract

Background

Breast conserving therapy (BCT) that include breast conserving surgery followed by adjuvant radiation therapy has revolutioned medicine by allowing women to avoid mastectomy. Accelerated partial breast irradiation (APBI) has emerged as a valid alternative to whole-breast irradiation that requires a shorter time commitment. We report our novel experience with APBI at a large public hospital that serves low-income and potentially noncompliant patients.

Methods

A retrospective chart review was conducted of women who underwent BCT for stage 0–IIA breast cancer from August 2007 to August 2010 treated with APBI with a brachytherapy catheter.

Results

Twenty-four patients (20 African American) were considered for APBI. Average age was 61 years. Four patients could not undergo APBI for technical reasons and completed whole-breast irradiation over a 5 week period. Median follow-up was 19 months. Nine patients (37.5 %) had ductal carcinoma-in-situ, and 15 patients (62.5 %) had invasive ductal carcinoma with an average tumor size of 1.1 cm. All patients had negative margins of >2 mm. Two patients (8 %) treated with the brachytherapy catheter had in-breast tumor recurrence. Thus, all 24 patients initially identified for APBI successfully completed adjuvant radiotherapy.

Conclusions

Patient compliance with postoperative irradiation is key to minimize local recurrence after BCT for breast cancer. This success with a brachytherapy catheter in underserved women in a U.S. public hospital setting indicates that outcomes of compliance and complications are comparable to nationally published results.

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Authors and Affiliations

  1. Division of Surgical Oncology, Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA

    Miral Amin MD, Sheryl Gabram MD & Monica Rizzo MD, FACS

  2. Avon Comprehensive Breast Center at Grady, Atlanta, GA, USA

    Miral Amin MD, Sheryl Gabram MD, Harvey Bumpers MD & Monica Rizzo MD, FACS

  3. Morehouse School of Medicine, Atlanta, GA, USA

    Harvey Bumpers MD

  4. Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, USA

    Jerome Landry MD, Ashesh B. Jani MD & Roberto Diaz MD

  5. Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA

    Jerome Landry MD, Ashesh B. Jani MD & Roberto Diaz MD

Authors
  1. Miral Amin MD
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  2. Sheryl Gabram MD
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  3. Harvey Bumpers MD
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  4. Jerome Landry MD
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  5. Ashesh B. Jani MD
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  6. Roberto Diaz MD
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  7. Monica Rizzo MD, FACS
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Corresponding author

Correspondence to Monica Rizzo MD, FACS.

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Amin, M., Gabram, S., Bumpers, H. et al. Feasibility of Accelerated Partial Breast Irradiation in a Large Inner-City Public Hospital. Ann Surg Oncol 19, 4094–4098 (2012). https://doi.org/10.1245/s10434-012-2444-x

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  • DOI: https://doi.org/10.1245/s10434-012-2444-x

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