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Emil L. Weber, Eric A. Goebel, Cerebral edema associated with Gliadel wafers: Two case studies, Neuro-Oncology, Volume 7, Issue 1, January 2005, Pages 84–89, https://doi.org/10.1215/S1152851704000614
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Abstract
While the introduction of carmustine wafers (Gliadel wafers) into the tumor resection cavity has been shown to be a beneficial therapy for malignant glioma, it is recognized that clinically significant cerebral edema is a potential adverse effect. Following are two clinical case reports demonstrating profound cerebral edema associated with implantation of Gliadel wafers. As a result, one of these individuals had premature death. A brief literature review is provided to assist in explaining the mechanisms by which clinically significant cerebral edema may develop.
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