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John H. Sampson, David A. Reardon, Allan H. Friedman, Henry S. Friedman, R. Edward Coleman, Roger E. McLendon, Ira Pastan, Darell D. Bigner, Sustained radiographic and clinical response in patient with bifrontal recurrent glioblastoma multiforme with intracerebral infusion of the recombinant targeted toxin TP-38: Case study, Neuro-Oncology, Volume 7, Issue 1, January 2005, Pages 90–96, https://doi.org/10.1215/S1152851703000589
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Abstract
Glioblastoma multiforme remains refractory to conventional therapy, and novel therapeutic modalities are desperately needed. TP-38 is a recombinant chimeric protein containing a genetically engineered form of the cytotoxic Pseudomonas exotoxin fused to transforming growth factor (TGF)-α. TGF-α binds with high affinity to the epidermal growth factor receptor, which is uniformly overexpressed in malignant gliomas, often because of gene amplification. Prior to therapy with TP-38, the patient described here was completely refractory to multiple other therapies, with radiographic and pathologic evidence of tumor progression. After therapy, she improved clinically, was weaned off steroids and anticonvulsants, and experienced a progressive decrease in enhancing tumor volume. Despite multiple prior recurrences, she has not progressed for >43 months after TP-38 therapy. Small remaining areas of enhancement demonstrate no evidence of tumor histologically and are hypometabolic on positron emission tomography. This report describes a dramatic and sustained clinical and radiographic response in a patient with a bifrontal glioblastoma multiforme treated with intratumoral infusion of a novel targeted toxin, TP-38.
References
Bobo, R.H., Laske, D.W., Akbasak, A., Morrison, P.F., Dedrick, R.L., and Oldfield, E.H. (
Brown, M.T., Coleman, R.E., Friedman, A.H., Friedman, H.S., McLendon, R.E., Reiman, R., Felsberg, G.J., Tien, R.D., Bigner, S.H., Zalutsky, M.R., Zhao, X.G., Wikstrand, C.J., Pegram, C.N., Herndon, J.E., 2nd, Vick, N.A., Paleologos, N., Fredericks, R.K., Schold, S.C., Jr., and Bigner, D.D. (
Frankel, A.E., Kreitman, R.J., and Sausville, E.A. (
Galanis, E., and Buckner, J. (
Grossi, P.M., Ochiai, H., Archer, G.E., McLendon, R.E., Zalutsky, M.R., Friedman, A.H., Friedman, H.S., Bigner, D.D., and Sampson, J.H. (
Hagihara, N., Walbridge, S., Olson, A.W., Oldfield, E.H., and Youle, R.J. (
Heimberger, A.B., Archer, G.E., McLendon, R.E., Hulette, C., Friedman, A.H., Friedman, H.S., Bigner, D.D., and Sampson, J.H. (
Imperato, J.P., Paleologos, N.A., and Vick, N.A. (
Jain, R.K. (
Kreitman, R.J., Wilson, W.H., White, J.D., Stetler-Stevenson, M., Jaffe, E.S., Giardina, S., Waldmann, T.A., and Pastan, I. (
Kreitman, R.J., Wilson, W.H., Bergeron, K., Raggio, M., Stetler-Stevenson, M., FitzGerald, D.J., and Pastan, I. (
Laske, D.W., Youle, R.J., and Oldfield, E.H. (
Libermann, T.A., Razon, N., Bartal, A.D., Yarden, Y., Schlessinger, J., and Soreq, H. (
Lieberman, D.M., Laske, D.W., Morrison, P.F., Bankiewicz, K.S., and Oldfield, E.H. (
McGirt, M.J., Villavicencio, A.T., Bulsara, K.R., Friedman, H.S., and Friedman, A.H. (
Morrison, P.F., Laske, D.W., Bobo, H., Oldfield, E.H., and Dedrick, R.L. (
Olsen, E., Duvic, M., Frankel, A., Kim, Y., Martin, A., Vonderheid, E., Jegasothy, B., Wood, G., Gordon, M., Heald, P., Oseroff, A., Pinter-Brown, L., Bowen, G., Kuzel, T., Fivenson, D., Foss, F., Glode, M., Molina, A., Knobler, E., Stewart, S., Cooper, K., Stevens, S., Craig, F., Reuben, J., Bacha, P., and Nichols, J. (
Pastan, I.H., Archer, G.E., McLendon, R.E., Friedman, H.S., Fuchs, H.E., Wang, Q.-C., Pai, L.H., Herndon, J., and Bigner, D.D. (
Rand, R.W., Kreitman, R.J., Patronas, N., Varricchio, F., Pastan, I., and Puri, R.K. (
Sampson, J.H., Akabani, G., Archer, G.E., Bigner, D.D., Berger, M.S., Friedman, A.H., Friedman, H.S., Herndon, J.E., II, Kunwar, S., Marcus, S., McLendon, R.E., Paolino, A., Penne, K., Provenzale, J., Quinn, J., Reardon, D.A., Rich, J., Stenzel, T., Tourt-Uhlig, S., Wikstrand, C., Wong, T., Williams, R., Yuan, F., Zalutsky, M.R., and Pastan, I. (
Torp, S.H., Helseth, E., Dalen, A., and Unsgaard, G. (
Wikstrand, C.J., Fung, K.-M., Trojanowski, J.Q., McLendon, R.E., and Bigner, D.D. (
Wikstrand, C.J., Stenzel, T., McLendon, R.E., and Bigner, D.D. (
Wong, A.J., Bigner, S.H., Bigner, D.D., Kinzler, K.W., Hamilton, S.R., and Vogelstein, B. (
Author notes
Duke University Medical Center, Durham, NC 27710 (J.H.S., D.A.R., A.H.F., H.S.F., R.E.C., R.E.M., D.D.B.);National Institutes of Health, Bethesda, MD 20892 (I.P.); USA
- anticonvulsants
- positron-emission tomography
- diagnostic radiologic examination
- exotoxins
- glioblastoma
- fusion proteins
- gene amplification
- genetic engineering
- pseudomonas
- epidermal growth factor receptors
- steroids
- transforming growth factors
- neoplasms
- targeted toxins
- tumor progression
- glioma, malignant
- affinity
- infusion procedures
- tumor volume
- binding (molecular function)