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Microparticulate Based Topical Delivery System of Clobetasol Propionate

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Abstract

Psoriasis is a chronic, autoimmune skin disease affecting approximately 2% of the world's population. Clobetasol propionate which is a superpotent topical corticosteroid is widely used for topical treatment of psoriasis. Conventional dosage forms like creams and ointments are commonly prefered for the therapy. The purpose of this study was to develop a new topical delivery system in order to provide the prolonged release of clobetasol propionate and to reduce systemic absorption and side effects of the drug. Clobetasol propionate loaded-poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by oil-in-water emulsion–solvent evaporation technique. Particle size analysis, morphological characterization, DSC and XRD analyses and in vitro drug release studies were performed on the microparticle formulations. Emulgel formulations were prepared as an alternative for topical delivery of clobetasol propionate. In vitro drug release studies were carried out from the emulgel formulations containing pure drug and drug-loaded microspheres. In addition, the same studies were performed to determine the drug release from the commercial cream product of clobetasol propionate. The release of clobetasol propionate from the emulgel formulations was significantly higher than the commercial product. In addition, the encapsulation of clobetasol propionate in the PLGA microspheres significantly delayed the drug release from the emulgel formulation. As a result, the decrease in the side effects of clobetasol propionate by the formulation containing PLGA microspheres is expected.

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DECLARATION OF INTEREST

This study was supported by the Management of Scientific Research Projects of Ankara University (Project Number: 07B3336002). The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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Authors and Affiliations

  1. Department of Pharmaceutical Technology, Faculty of Pharmacy, Ankara University, Tandogan, 06100, Ankara, Turkey

    Ulya Badıllı, Tangül Şen & Nilüfer Tarımcı

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  1. Ulya Badıllı
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  2. Tangül Şen
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  3. Nilüfer Tarımcı
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Correspondence to Nilüfer Tarımcı.

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ANSWERS TO REVIEWER 3

1. The use of English in this manuscript was thoroughly checked by a native speaker.

2. The explanation (“The different thermodynamic activities between formulations could also have accounted for these results”) was added into the “RESULTS AND DISCUSSION” section on the advice of the reviewer.

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Badıllı, U., Şen, T. & Tarımcı, N. Microparticulate Based Topical Delivery System of Clobetasol Propionate. AAPS PharmSciTech 12, 949–957 (2011). https://doi.org/10.1208/s12249-011-9661-7

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