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Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery

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Abstract

l-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface area-to-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats may provide an attractive alternative to the commercial facial cotton masks.

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References

  1. Segall AI, Moyano MA. Stability of vitamin C derivatives in topical formulations containing lipoic acid, vitamins A and E. Int J Cosmet Sci. 2008;30:453–8.

    Article  CAS  PubMed  Google Scholar 

  2. Gaspar LR, Campo PMBGM. Photostability and efficacy studies of topical formulations containing UV-filters combination and vitamins A C and E. Int J Pharm. 2007;343:181–9.

    Article  CAS  PubMed  Google Scholar 

  3. Pinnell SR, Madey DL. Topical vitamin C in skin care. Aesthet Surg J. 1998;18:468–70.

    Article  CAS  PubMed  Google Scholar 

  4. Farahmand S, Tajerzadeh H, Farboud ES. Formulation and evaluation of a vitamin C multiple emulsion. Pharm Dev Technol. 2006;11:255–61.

    Article  CAS  PubMed  Google Scholar 

  5. Rozman B, Gašperlin M. Stability of vitamins C and E in topical microemulsions for combined antioxidant therapy. Drug Deliv. 2007;14:235–45.

    Article  CAS  PubMed  Google Scholar 

  6. Kogan A, Garti N. Microemulsions as transdermal drug delivery vehicles. Adv Colloid Interface Sci. 2006;123–126:369–85.

    Article  PubMed  Google Scholar 

  7. Watson REB, Long SP, Bowden JJ, Bastrilles JY, Barton SP, Griffiths CEM. Repair of photoaged dermal matrix by topical application of a cosmetic ‘antiageing’ product. Br J Dermatol. 2008;158:472–7.

    Article  CAS  PubMed  Google Scholar 

  8. Cao C, Wan S, Jiang Q, Amaral A, Lu S, Hu G, et al. All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes. J Cell Physiol. 2008;215:506–16.

    Article  CAS  PubMed  Google Scholar 

  9. Kang S, Voorhees JJ. Photoaging therapy with topical tretinoin, an evidence based analysis. J Am Acad Dermatol. 1998;39:S55–61.

    Article  CAS  PubMed  Google Scholar 

  10. Fisher GJ, Kang S, Varani J, Bata-Csorgo Z, Wan Y, Datta S, et al. Mechanisms of photoaging and chronological skin aging. Arch Dermatol. 2002;138:1462–70.

    Article  CAS  PubMed  Google Scholar 

  11. Thielitz A, Abdel-Naser MB, Fluhr JW, Zouboulis CC, Gollnick H. Topical retinoids in acne: An evidence-based overview. J Dtsch Dermatol Ges. 2008;6:1023–31.

    Article  PubMed  Google Scholar 

  12. Lin HS, Chean CS, Ng YY, Chan SY, Ho PC. 2-Hydroxypropyl-b-cyclodextrin increases aqueous solubility and photostability of all-trans-retinoic acid. J Clin Pharm Ther. 2000;25:265–9.

    Article  CAS  PubMed  Google Scholar 

  13. Montassier P, Duchene D, Poelman MC. Inclusion complexes of tretinoin with cyclodextrins. Int J Pharm. 1997;153:199–209.

    Article  CAS  Google Scholar 

  14. Hu LD, Tang X, Cui FD. Solid lipid nanoparticles (SLNs) to improve oral bioavailability of poorly soluble drugs. J Pharm Pharmocol. 2004;56:1527–35.

    Article  CAS  Google Scholar 

  15. Sonavane G, Tomoda K, Sano A, Ohshima H, Terada H, Makino K. In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size. Colloids Surf B Biointerfaces. 2008;65:1–10.

    Article  CAS  PubMed  Google Scholar 

  16. Menon GK, Brandsma JL, Schwartz PM. Particle-mediated gene delivery and human skin: Ultrastructural observations on stratum corneum barrier structures. Skin Pharmacol Physiol. 2007;20:141–7.

    Article  CAS  PubMed  Google Scholar 

  17. Mulholland WJ, Arbuthnott EAH, Bellhouse BJ, Cornhill JF, Austyn JM, Kendall MAF, et al. Multiphoton high-resolution 3d imaging of langerhans cells and keratinocytes in the mouse skin model adopted for epidermal powdered immunization. J Invest Dermatol. 2006;126:1541–8.

    Article  CAS  PubMed  Google Scholar 

  18. Dean HJ, Haynes J, Schmaljohn C. The role of particle-mediated DNA vaccines in biodefense preparedness. Adv Drug Deliv Rev. 2005;57:1315–42.

    Article  CAS  PubMed  Google Scholar 

  19. Mannila J, Järvinen T, Järvinen K, Tarvainen M, Jarho P. Effects of RM-β-CD on sublingual bioavailability of Δ9-tetrahydrocannabinol in rabbits. Eur J Pharm Sci. 2005;26:71–7.

    Article  CAS  PubMed  Google Scholar 

  20. de Araujo DR, Tsuneda SS, Cereda CMS, Carvalho FDGF, Preté PSC, Fernandes SA, et al. Development and pharmacological evaluation of ropivacine-2- hydroxypropyl-b-cyclodextrin inclusion complex. Eur J Pharm Sci. 2008;33:60–71.

    PubMed  Google Scholar 

  21. Pfitzner I, Francz PI, Biesalski UK. Carotenoid: methyl-b3-cyclodextrin formulations: An improved method for supplementation of cultured cells. Biochim Biophys Acta. 2000;1474:163–8.

    CAS  PubMed  Google Scholar 

  22. Taepaiboon P, Rungsardthong U, Supaphol P. Drug-loaded electrospun mats of poly (vinyl alcohol) fibres and their release characteristics of four model drugs. Nanotechnology. 2006;17:2317–29.

    Article  CAS  Google Scholar 

  23. Kenawy E-R, Abdel-Hay FI, El-Newehy MH, Wnek GE. Controlled release of ketoprofen from electrospun poly(vinyl alcohol) nanofibers. Mater Sci Eng A. 2007;459:390–6.

    Article  Google Scholar 

  24. Verreck G, Chun I, Rosenblatt J, Peeters J, Dijck AV, Mensch J, et al. Incorporation of drugs in an amorphous state into electrospun nanofibers composed of water-insoluble, nonbiodegradable polymer. J Control Release. 2003;92:349–60.

    Article  CAS  PubMed  Google Scholar 

  25. Taepaiboon P, Rungsardthong U, Supaphol P. Vitamin-loaded electrospun cellulose acetate nanofiber mats as transdermal and dermal therapeutic agents for vitamin A acid and vitamin E. Eur J Pharm Biopharm. 2007;67:387–97.

    Article  CAS  PubMed  Google Scholar 

  26. Bai J, Li Y, Yang S, Du J, Wang S, Zheng J, et al. A simple and effective route for the preparation of poly (vinylalcohol) (PVA) nanofibers containing gold nanoparticles by electrospinning method. Solid State Commun. 2007;141:292–5.

    Article  CAS  Google Scholar 

  27. Wang Y, Li Y, Sun G, Zhang G, Liu H, Du J, et al. Fabrication of Au/PVP nanofiber composites by electrospinning. J Appl Polym Sci. 2007;105:3618–22.

    Article  CAS  Google Scholar 

  28. Kligman AM, Christophers E. Preparation of isolated sheets of human stratum corneum. Arch Dermatol. 1963;88:702–5.

    CAS  PubMed  Google Scholar 

  29. Gaspar LR, Campos PM. Evaluation of the photostability of different UV filter combinations in a sunscreen. Int J Pharm. 2006;307:123–8.

    Article  CAS  PubMed  Google Scholar 

  30. Bai J, Yang Q, Li M, Wang S, Zhang C, Li Y. Preparation of composite nanofibers containing gold nanoparticles by using poly (N-vinylpyrrolidone) and β- cyclodextrin. Mater Chem Phys. 2008;111:205–8.

    Article  CAS  Google Scholar 

  31. Şanlı O, Ay N, Işıklan N. Release characteristics of diclofenac sodium from poly (vinyl alcohol)/sodium alginate and poly (vinyl alcohol)-grafted-poly (acrylamide)/sodium alginate blend beads. Eur J Pharm Biopharm. 2007;65:204–14.

    Article  PubMed  Google Scholar 

  32. Hong J, Hong CK, Shim SE. Synthesis of polystyrene microspheres by dispersion polymerization using poly (vinyl alcohol) as a steric stabilizer in aqueous alcohol media. Colloids Surf A Physicochem Eng Asp. 2007;302:225–33.

    Article  CAS  Google Scholar 

  33. Arndt KF, Richter A, Ludwig S, Zimmermann J, Kressler J, Kuckling D, et al. Poly (vinyl alcohol)/poly (acrylic acid) hydrogels: FT-IR spectroscopic characterization of crosslinking reaction and work at transition point. Acta Polym. 1999;50:383–90.

    Article  CAS  Google Scholar 

  34. Khanna PK, Gokhale R, Subbarao VVVS, Kasi Vishwanath A, Das BK, Satyanarayana CVV. A simple and effective route for the preparation of poly (vinylalcohol) (PVA) nanofibers containing gold nanoparticles by electrospinning method. Mater Chem Phys. 2005;92:229–33.

    Article  CAS  Google Scholar 

  35. Garnero C, Longhi M. Study of ascorbic acid interaction with hydroxypropyl-β-cyclodextrin and triethanolamin, separately and in combination. J Pharm Biomed Anal. 2007;45:536–45.

    Article  CAS  PubMed  Google Scholar 

  36. Sionkowska A, Skopiska J, Wishiewski M. Photochemical stability of collagen/poly (vinyl alcohol) blends. Polymer Degrad Stability. 2004;83:117–25.

    Article  CAS  Google Scholar 

  37. Fathi-Azarbayjani A, Chan SY. Single and multi-layered nanofibers for rapid and controlled drug delivery. Chem Pharm Bull. 2010;58:143–6.

    Article  CAS  PubMed  Google Scholar 

  38. Angberg M, Nyström C, Castensson S. Evaluation of heat-conduction microcalorimetry in pharmaceutical stability studies VII. Oxidation of ascorbic acid in aqueous solution. Int J Pharm. 1993;90:19–33.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacy, National University of Singapore, Block S4, level 2, Science Drive 4, 117543, Singapore, Singapore

    Anahita Fathi-Azarbayjani, Lin Qun & Sui Yung Chan

  2. Department of Anesthesiology, Singapore General Hospital, 169608, Singapore, Singapore

    Yew Weng Chan

Authors
  1. Anahita Fathi-Azarbayjani
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  2. Lin Qun
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  3. Yew Weng Chan
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  4. Sui Yung Chan
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Correspondence to Sui Yung Chan.

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Fathi-Azarbayjani, A., Qun, L., Chan, Y.W. et al. Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery. AAPS PharmSciTech 11, 1164–1170 (2010). https://doi.org/10.1208/s12249-010-9475-z

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  • DOI: https://doi.org/10.1208/s12249-010-9475-z

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