References
DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ. 2003;22(2):151–85.
Adams CP, Brantner VV. Spending on new drug development. Heal Econ. 2010;19(2):130–41.
O’ Hara DM, Theobald V, Egan A, Usansky J, Krishna M, TerWee J, Maia M, Spriggs F, Kenney J, Safavi A, Keefe J. Ligand binding assays in the 21st century laboratory: recommendations for characterization and supply of critical reagents. AAPS J. 2012. doi:10.1208/s12248-012-9334-9.
Spriggs FP, Zhandong DZ, Safavi A, Jani D, Dontha N, Kant A, Ly J, Brilando L, Osterlund K, Rouleau N, Fischer S, Boissonneault M, Ray CA. Ligand binding assays in the 21st century laboratory: platforms. AAPS J. 2012;14(1):113–8.
Ahene AB, Morrow C, Rusnak D, Spitz S, Usansky J, Pils H, Civoli F, Pandya K, Sue B, Leach D, Derent J. Ligand binding assays in the 21st century: automation. AAPS J. 2012;14(1):142–53.
Leung SS, Usansky J, Lynde R, Thway T, Hendricks R, Rusnak D. Ligand-binding assays in the 21st century laboratory: recommendations for an automated data interchange process. AAPS J. 2012;14(1):105–12.
Mueller SG, Weiner MW, Thal LJ, Petersen RC, Jack CR, Jagust W, Trojanowski JQ, Toga AW, Beckett L. Ways toward an early diagnosis in Alzheimer’s disease: the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Alzheimers Dement. 2005;1(1):55–66.
Jarvis LM. Chem Eng News. 2010;88(23):14–5.
The Writing Group for the WHI Investigators. Risks and benefits of estrogen plus progestin in healthy post-menopausal women: principal results of the Women’s Health Initiative randomized controlled trial. JAMA. 2002;288(3):321–33.
Freedom CAR and Fuel Partnership 2010 Highlights of Technical Accomplishments. (2010). Retrieved January 5, 2012, from http://www1.eere.energy.gov/vehiclesandfuels/pdfs/program/2010_fcfp_accomplishments_rpt.pdf
Acknowledgments
The authors would like to acknowledge the significant contributions made by AAPS staff and all of the many volunteers. We would also like to recognize the leadership provided by the members of the action program committee and the sub-team leaders: Jean Lee, Valerie Quarmby, Marian Kelley, Franklin Spriggs, Denise O’ Hara, and Sheldon Leung. We would also like to recognize the many authors that spent countless hours discussing, debating, and honing the messages found in this theme issue.
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Guest Editors: William Nowatzke, Ago Ahene, and Chad Ray
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Ray, C.A., Ahene, A.B. Ligand Binding Assays in the 21st Century Laboratory—A Call for Change. AAPS J 14, 377–379 (2012). https://doi.org/10.1208/s12248-012-9351-8
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DOI: https://doi.org/10.1208/s12248-012-9351-8