ABSTRACT

Entering the 21st century, scientific frontiers have moved to a

new horizon toward understanding the entire biological systems.

Revealing the enzymes’ functions on the basis of their primary

sequences and substrate structures is a new approach to reach this

mega goal. It presents a great opportunity and also an unparalleled

challenge due to the vast volume of data. Biocatalysis has supplied

seminal knowledge. On the foundation of this, combining the

use of databases created of experimental data of enzyme activity

and computational methods such as molecular modeling and

bioinformatics tool makes it possible to establish the relationship

between enzymes’ primary sequences and their catalytic functions.

In this chapter, a discussion is provided and a model is proposed on

the basis of review of amassed literatures and distilled information,

with emphasis on the potentially useful technologies.