Journal of Lipid Research
Research ArticlesDecreased ω-6:ω-3 PUFA ratio attenuates ethanol-induced alterations in intestinal homeostasis, microbiota, and liver injury
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This work was supported by National Institutes of Health Grants R01AA024102-01A1 (I.A.K.), U01AA022489 (C.J.M.), 1U01AA021901-01 (C.J.M.), 1U01AA021893-01 (C.J.M.), R01AA023681 (C.J.M.), S10OD020106 (X.Z.), P20GM103436 (E.C.R.), and P30GM106396 (E.C.R.); U.S. Department of Veterans Affairs Grant I01BX000350 (C.J.M.). Research reported in this publication was also supported by an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health under Grant P20GM113226 (C.J.M.) and the National Institute on Alcohol Abuse and Alcoholism of the National Institutes of Health under Grant P50AA024337 (C.J.M.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The authors declare that they have no conflicts of interest with the contents of this article.
The online version of this article (available at http://www.jlr.org) contains a supplement.
- AA
arachidonic acid
- Adh
alcohol dehydrogenase
- ALD
alcoholic liver disease
- Aldh
aldehyde dehydrogenase
- Alpi
intestinal alkaline phosphatase
- ALT
alanine aminotransferase
- AMP
antimicrobial peptide
- BA
bile acid
- CAE
chloroacetate esterase
- Car
constitutive androstane receptor
- CDCA
chenodeoxycholic acid
- DSS
dextran sulfate sodium
- EtOH
ethanol
- fat-1
ω-3 FA desaturase-1
- 5-HT
5-hydroxytryptamine
- ISC
intestinal stem cell
- I3S
3-indoxyl sulfate
- LCA
lithocholic acid
- Leap2
liver-enriched antimicrobial peptide 2
- LPS
lipopolysaccharide
- OTU
operational taxonomic unit
- PF
pair-fed
- Pxr
pregnane X receptor
- RvD1
resolvin D1
- SPM
specialized pro-resolving mediator
- TG
triglyceride
- Tlr
Toll-like receptor
- Tph-1
tryptophan hydroxylase-1
- UC
ulcerative colitis
- UDCA
ursodeoxycholic acid
Abbreviations: