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Are Neurotrophin Genes Involved in the Pathophysiology of Gambling Disorder?

Published online by Cambridge University Press:  01 September 2022

I. Baenas ,
N. Solé-Morata ,
M. Etxandi ,
R. Granero ,
M. Gené ,
C. Barrot ,
P. Gorwood ,
N. Ramoz ,
F. Fernandez-Aranda  and
S. Jimenez-Murcia
I. Baenas*
Affiliation:
Hospital Universitario de Bellvitge, Psiquiatría, L’Hospitalet de Llobregat, Spain Instituto de Salud Carlos III, Ciber Fisiopatología De La Obesidad Y Nutrición, Madrid, Spain
N. Solé-Morata
Affiliation:
Hospital Universitario de Bellvitge, Psiquiatría, L’Hospitalet de Llobregat, Spain
M. Etxandi
Affiliation:
Hospital Universitario de Bellvitge, Psiquiatría, L’Hospitalet de Llobregat, Spain
R. Granero
Affiliation:
Instituto de Salud Carlos III, Ciber Fisiopatología De La Obesidad Y Nutrición, Madrid, Spain Autonomous University of Barcelona, Department Of Psychobiology And Methodology, Bellaterra, Spain
M. Gené
Affiliation:
Laboratorio de Genética, Unidad de Medicina Legal y Toxicología, Facultad de Medicina, Universidad de Barcelona, Ciencias Clínicas, Barcelona, Spain
C. Barrot
Affiliation:
Laboratorio de Genética, Unidad de Medicina Legal y Toxicología, Facultad de Medicina, Universidad de Barcelona, Ciencias Clínicas, Barcelona, Spain
P. Gorwood
Affiliation:
Unisersité Paris Descartes, Cmme, Hopital Sainte-anne Ghu Paris Psychiatrie Et Neurosciences, Paris, France
N. Ramoz
Affiliation:
Unisersité Paris Descartes, Cmme, Hopital Sainte-anne Ghu Paris Psychiatrie Et Neurosciences, Paris, France
F. Fernandez-Aranda
Affiliation:
Hospital Universitario de Bellvitge, Psiquiatría, L’Hospitalet de Llobregat, Spain Instituto de Salud Carlos III, Ciber Fisiopatología De La Obesidad Y Nutrición, Madrid, Spain School of Medicine and Health Sciences, University of Barcelona, Department Of Clinical Sciences, Barcelona -Campus Bellvitge, Spain University Hospital of Bellvitge,-IDIBELL, Department Of Psychiatry, Hospitalet de Llobregat, Spain
S. Jimenez-Murcia
Affiliation:
Hospital Universitario de Bellvitge, Psiquiatría, L’Hospitalet de Llobregat, Spain Instituto de Salud Carlos III, Ciber Fisiopatología De La Obesidad Y Nutrición, Madrid, Spain School of Medicine and Health Sciences, University of Barcelona, Department Of Clinical Sciences, Barcelona -Campus Bellvitge, Spain Instituto de Investigación Biomédica de Bellvitge (IDIBELL), Grupo Psiquiatría Y Salud Mental-programa Neurociencias, Hospitalet de Llobregat, Spain
*
*Corresponding author.

Abstract

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Introduction

Gambling Disorder (GD) is considered a multifactorial behavioral addictive disorder, leading to severe psychological, social and economic consequences. Previous studies have investigated genetic mechanisms underlying GD. Growing literature showed a possible link between addiction-related disorders and neurotrophic factors (NTF), involved in synaptic plasticity and neuronal survival. Thus, the study of NTF genes emerged as promising targets in the field of GD.

Objectives

To evaluate genetic implications of the NTF family in the pathophysiology GD. We hypothesized the involvement of some NTF genes polymorphisms in the onset and progression of GD as potential biological risk factors.

Methods

The sample was composed by 166 individuals with GD and 191 healthy controls. 36 Single nucleotide polymorphisms (SNPs) from NTF (NGF, NGFR, NTRK1, BDNF, NTRK2, NTF3, NTRK3, NTF4, CNTF and CNTFR) were selected and genotyped. Linkage disequilibrium and haplotype constructions were assessed, related to the presence of GD. Moreover, regulatory elements overlapping the identified SNPs variants associated with GD was also analyzed.

Results

6 SNPs were potentially associated to GD after the comparisons of allele frequencies between groups. Single and multiple-marker analyses showed a strong association between both NTF3 and NTRK2 genes, and GD.

Conclusions

This study suggests the implication of NTF genes in the development of GD, being the altered cross-regulation of some NTF factors signalling pathways, a potential biological vulnerability factor in GD. Fundings and Acknowledgements: Ministerio de Ciencia, Innovación y Universidades (RTI2018-101837-B-100) Delegación del Gobierno para el Plan Nacional sobre Drogas (2017I067, 2019I47), Instituto Salud Carlos III (ISCIII) (PI17/01167, PI20/00132) and CIBERObn, an initiative of ISCIII.

Disclosure

No significant relationships.

Keywords

Neurotrophin genesSNPsHaplotypesGambling Disorder
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S240 - S241
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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