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The impact of Mild Behavioral Impairment on the individual’s level of psychological, social, and occupational functioning

Published online by Cambridge University Press:  01 September 2022

C. Elefante ,
G.E. Brancati ,
T. Gemmellaro ,
S. Ricciardulli ,
F. Romeo ,
S. Torrigiani ,
G. Pistolesi ,
S. Amadori ,
L. Lattanzi  and
G. Perugi
C. Elefante*
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
G.E. Brancati
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
T. Gemmellaro
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
S. Ricciardulli
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
F. Romeo
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
S. Torrigiani
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
G. Pistolesi
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
S. Amadori
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
L. Lattanzi
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
G. Perugi
Affiliation:
University of Pisa, Department Of Clinical And Experimental Medicine, Pisa, Italy
*
*Corresponding author.

Abstract

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Introduction

Mild behavioral impairment (MBI) is a neurobehavioral syndrome characterized by later-life emergent neuropsychiatric symptoms, which represent an at-risk state for incident cognitive decline and dementia.

Objectives

Our obective was to prospectively evaluate the impact of MBI on global functioning in patients ≥ 50 years with a major depressive episode (MDE) at baseline.

Methods

We recruited 51 patients ≥ 50 years presenting with a MDE at the outpatient clinic of the 2nd Psychiatric Unit of the University of Pisa. Then we selected those patients who had a follow-up of at least two months and excluded subjects with a neurodegenerative disease. The included patients (N = 25) were subdivided in a subgroup with MBI and a subgroup without MBI. The subgroups have been compared for the difference between baseline and follow-up score in global functioning according Global Assessment of Functioning (GAF) scale. Comparative analyses were conducted by means of mixed anova.

Results

There was a significant interaction effect between time and the MBI condition (F[1, 23] = 4.12, p = 0.05 η p 2 = 0.15). Descriptive statistics showed that while patients without MBI showed higher GAF score at follow-up (mean = 65.12) compared to GAF score at baseline (mean = 54.37), patients with MBI showed, on average, the same GAF score at follow-up (mean = 54.44) and at baseline (mean = 54.44).

Conclusions

In patients with MDE, the presence of MBI is related to a lack of improvement in psychological, social, and occupational functioning in the short-term

Disclosure

No significant relationships.

Keywords

Mild Behavioral Impairment (MBI)Neuropsychiatric symptomsPreclinical dementiaglobal functioning
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S172
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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