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Swine Granulosa Cells Show Typical Endothelial Cell Characteristics

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Abstract

Granulosa cells, which belong to the somatic compartment of the ovarian follicle, are actively involved as endocrine cells in follicle growth. Recently, it has been proposed that these cells are not terminally differentiated and possess multipotency. Therefore, we cultured swine granulosa cells in specific endothelial cell culture medium (EBM-2), and phenotypic and functional characteristics of endothelial cells were assessed. The collected data suggest that these endocrine cells can also behave as endothelial cells, therefore potentially contributing to follicular angiogenesis, a crucial process in follicle growth and selection.

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Authors and Affiliations

  1. Dipartimento di Scienze Medico-Veterinarie, Università degli Studi di Parma, Via del Taglio 10, 43126, Parma, Italy

    Giuseppina Basini MS, PhD, Irene Falasconi MS, Simona Bussolati, Stefano Grolli DVM, PhD, Rosanna Di Lecce DVM, PhD & Francesca Grasselli DVM, PhD

Authors
  1. Giuseppina Basini MS, PhD
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  2. Irene Falasconi MS
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  3. Simona Bussolati
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  4. Stefano Grolli DVM, PhD
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  5. Rosanna Di Lecce DVM, PhD
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  6. Francesca Grasselli DVM, PhD
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Correspondence to Giuseppina Basini MS, PhD.

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Basini, G., Falasconi, I., Bussolati, S. et al. Swine Granulosa Cells Show Typical Endothelial Cell Characteristics. Reprod. Sci. 23, 630–637 (2016). https://doi.org/10.1177/1933719115612130

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  • DOI: https://doi.org/10.1177/1933719115612130

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