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Matrix Metalloproteinases 2 and 9 and E-Cadherin Expression in the Endometrium During the Implantation Window of Infertile Women Before In Vitro Fertilization Treatment

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Abstract

Objective

To evaluate the expression of endometrial matrix metalloproteinases (MMPs) 2 and 9 and E-cadherin in peri-implantation phase of infertile women who have undergone in vitro fertilization (IVF) cycles.

Methods

This prospective study included 51 patients who underwent endometrial biopsy during the receptive phase in a menstrual cycle prior to IVF treatment. The samples were evaluated by tissue microarray for immunohistochemical study.

Results

The expression of MMP-2, MMP-9, and E-cadherin in the endometrium prior to IVF treatment was not associated with pregnancy. There was a decrease in E-cadherin immunodetection, the higher the age of the patients, a negative relationship between E-cadherin and MMP-2, and a positive association between MMP-9 and E-cadherin.

Conclusions

The MMP-2, MMP-9, and E-cadherin are expressed in the endometrium of infertile patients during the receptive phase of the natural menstrual cycle. However, there is no correlation between the expression of these molecules and the clinical IVF outcomes.

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Authors and Affiliations

  1. Gynecology Department of Paulista School of Medicine, Federal University of Sao Paulo (EPM-UNIFESP), Sao Paulo, Brazil

    Vamberto O. A. Maia-Filho MD, PhD, Fernando P. Ferreira MD, PhD, Tatiana C. S. Bonetti PhD & Eduardo L. A. Motta MD, PhD

  2. Centre of Human Reproduction, Hospital e Maternidade Santa Joana, São Paulo, Brazil

    Vamberto O. A. Maia-Filho MD, PhD, Fernando P. Ferreira MD, PhD, Paulo Serafini MD, PhD & Eduardo L. A. Motta MD, PhD

  3. Huntington Reproductive Medicine, Av República do Líbano, São Paulo, Brazil

    Andre M. Rocha PhD, Paulo Serafini MD, PhD & Eduardo L. A. Motta MD, PhD

  4. Gynecology Discipline of School of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil

    Paulo Serafini MD, PhD

Authors
  1. Vamberto O. A. Maia-Filho MD, PhD
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  2. Andre M. Rocha PhD
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  3. Fernando P. Ferreira MD, PhD
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  4. Tatiana C. S. Bonetti PhD
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  5. Paulo Serafini MD, PhD
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  6. Eduardo L. A. Motta MD, PhD
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Correspondence to Vamberto O. A. Maia-Filho MD, PhD.

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Maia-Filho, V.O.A., Rocha, A.M., Ferreira, F.P. et al. Matrix Metalloproteinases 2 and 9 and E-Cadherin Expression in the Endometrium During the Implantation Window of Infertile Women Before In Vitro Fertilization Treatment. Reprod. Sci. 22, 416–422 (2015). https://doi.org/10.1177/1933719114529373

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