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Differential Expression of Serum Glycodelin and Insulin-Like Growth Factor Binding Protein 1 in Early Pregnancy

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Abstract

This prospective study evaluated whether serum glycodelin and insulin-like growth factor binding protein 1 (IGFBP-1) predict the likelihood of embryo implantation in recipients undergoing donor egg in vitro fertilization. We measured glycodelin and IGFBP-1 at 6 points from lining check to lutenizing hormone (LH) + 31. β-Human chorionic gonadotropin levels were first measured at LH + 17. The recipients were divided into those without embryo implantation (group 1, n = 6) and those with successful implantation (group 2, n = 30). Although this is a negative study in that neither glycodelin nor IGFBP-1 alone reflected endometrial (EM) receptivity, the glycodelin/IGFBP-1 ratio on the day of blastocyst transfer was higher in recipients who achieved pregnancy (P = .05). At LH + 17, glycodelin was higher (P = .04), and IGFBP-1 was lower (P = .004) in recipients who achieved pregnancy when compared to those who did not. These observations are likely due to EM changes induced by successful embryo implantation.

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Authors and Affiliations

  1. Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, New York Presbyterian Hospital, Columbia University Medical Center, 622 West 168th Street, PH 16-64, New York, NY, 10032, USA

    Nataki C. Douglas MD, PhD, Melvin H. Thornton II MD, Sahadat K. Nurudeen MD, Maria Bucur MD, Rogerio A. Lobo MD & Mark V. Sauer MD

Authors
  1. Nataki C. Douglas MD, PhD
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  2. Melvin H. Thornton II MD
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  3. Sahadat K. Nurudeen MD
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  4. Maria Bucur MD
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  5. Rogerio A. Lobo MD
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  6. Mark V. Sauer MD
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Correspondence to Nataki C. Douglas MD, PhD.

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Douglas, N.C., Thornton, M.H., Nurudeen, S.K. et al. Differential Expression of Serum Glycodelin and Insulin-Like Growth Factor Binding Protein 1 in Early Pregnancy. Reprod. Sci. 20, 1376–1381 (2013). https://doi.org/10.1177/1933719113485290

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