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ResearchIn-Press PreviewBone biology Open Access | 10.1172/JCI166795
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Li, X. in: JCI | PubMed | Google Scholar |
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Liang, T. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Dai, B. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Chang, L. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Zhang, Y. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Hu, S. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Guo, J. in: JCI | PubMed | Google Scholar |
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Xu, S. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Zheng, L. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Yao, H. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Lian, H. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Nie, Y. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Li, Y. in: JCI | PubMed | Google Scholar |
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by He, X. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Yao, Z. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Tong, W. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Wang, X. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
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1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Xu, J. in: JCI | PubMed | Google Scholar
1Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, China
2Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univerisity of Hong Kong, Hong Kong, China
3School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China
4Beijing Key Laboratory of Preclinical Research and Evaluation for Cardiovas, Fuwai Hospital, National Centre for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
5State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China
6Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese Univeristy of Hong Kong, Hong Kong, China
7Musculoskeletal Research Laboratory, Department of Orthopedics & Traumatolo, The Chinese University of Hong Kong, Hong Kong, Hong Kong
8Centre for Translational Medicine Research and Development, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China
Find articles by Qin, L. in: JCI | PubMed | Google Scholar
Published March 21, 2024 - More info
Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remains unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass. The primary effect of glucocorticoids on osteogenic differentiation was not inhibitory; instead, they cooperated with macrophages to facilitate osteogenesis. Impaired local nutrient status, notably, obstructed fatty acid transportation, was a key factor contributing to glucocorticoid-induced impairment of bone turnover in vivo. Furthermore, fatty acid oxidation in macrophages fueled the ability of glucocorticoid-liganded receptors to enter the nucleus and then promoted the expression of Bmp2, a key cytokine that facilitates osteogenesis. Metabolic reprogramming by localized fatty acid delivery partly rescued glucocorticoid-induced pathology by restoring a healthier immune-metabolic milieu. These data provide insights into the multifactorial metabolic mechanisms by which glucocorticoids generate skeletal disorders, thus suggesting possible therapeutic avenues.