Advertisement
Concise Publication Free access | 10.1172/JCI107261
Renal and Hypertension Service, the Department of Medicine, and the Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048
Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90048
Find articles by Kurokawa, K. in: JCI | PubMed | Google Scholar
Renal and Hypertension Service, the Department of Medicine, and the Medical Research Institute, Cedars-Sinai Medical Center, Los Angeles, California 90048
Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, California 90048
Find articles by Massry, S. in: JCI | PubMed | Google Scholar
Published April 1, 1973 - More info
Isoproterenol and norepinephrine (10-4 M) significantly increased cyclic AMP formation and glucose production by the isolated tubules of the renal cortex of the rat. These effects were abolished by propranolol. Theophylline diminished the effects of the catecholamines on gluconeogenesis despite a marked augmentation in cyclic AMP concentration. In the absence of calcium ion in the incubation medium, isoproterenol stimulates cyclic AMP production, but has no effect on gluconeogenesis. It is concluded that catecholamines enhance gluconeogenesis in renal cortical tubules by the stimulation of beta adrenergic receptors. This effect is probably mediated through adenyl cyclase-cyclic AMP system and requires an adequate level of ATP and the presence of calcium ion.
Images.
Click on an image below to see the page. View PDF of the complete article